Katayama I, Asai T, Nishiyama S, Nishioka K
Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan.
J Dermatol. 1991 Feb;18(2):63-8. doi: 10.1111/j.1346-8138.1991.tb03044.x.
Lymphocyte response to staphylococcal enterotoxin B (SEB) was analysed in 11 cases with Sjögren syndrome (SjS) who developed annular erythema during the course. Increased lymphocyte response against SEB was observed on day 5 in those patients who developed annular erythema at the time of examination. A similar reaction pattern was observed when Con A and PWM, but not protein A, were used as the mitogen. No significant lymphocyte response was observed in the patients in the inactive stage without annular erythema or in normal controls. Furthermore, peripheral blood lymphocytes express LFA-1 after SEB stimulation. These results suggest that lymphocytes from SjS patients react to various types of antigenic or mitogenic stimulation and that they express cell adhesion molecules, especially in patients with active annular erythema.
对11例在病程中出现环形红斑的干燥综合征（SjS）患者的淋巴细胞对葡萄球菌肠毒素B（SEB）的反应进行了分析。在检查时出现环形红斑的患者中，第5天观察到针对SEB的淋巴细胞反应增加。当使用刀豆球蛋白A（Con A）和美洲商陆有丝分裂原（PWM）而非蛋白A作为有丝分裂原时，观察到类似的反应模式。在无环形红斑的非活动期患者或正常对照中未观察到明显的淋巴细胞反应。此外，外周血淋巴细胞在SEB刺激后表达淋巴细胞功能相关抗原-1（LFA-1）。这些结果表明，SjS患者的淋巴细胞对各种类型的抗原或有丝分裂原刺激有反应，并且它们表达细胞粘附分子，尤其是在患有活动性环形红斑的患者中。
