Yamamoto T, Katayama I, Nishioka K
Department of Dermatology, Tokyo Medical and Dental University School of Medicine, Japan.
J Dermatol Sci. 1996 Dec;13(3):212-8. doi: 10.1016/s0923-1811(96)00537-3.
Sjgren syndrome (SjS) is an auto-immune disease and immunological mechanisms have recently been suggested in the pathogenesis of psoriasis; however, co-existence of these diseases is relatively rare. To determine whether or not there exist the nature of common underlying abnormalities, five patients with psoriasis and SjS were studied. Two patients had psoriasis vulgaris (PV), two had psoriasis arthropathica (PA), and the other had generalized pustular psoriasis (GPP). Lymphocyte response against staphylococcal enterotoxin B was examined by 3H-thymidine incorporation. In one patient with GPP, T-cell receptor (TCR) V beta repertoire of infiltrating T-cells into the lesional skin was examined by reverse transcriptase-polymerase chain reaction (RT-PCR). Stimulation index (S.I.) level of patients with psoriasis and SjS did not show any significant increases compared with patients with psoriasis or SjS alone; however, one patient with PV and SjS, who showed several serological immune imbalances, demonstrated a significant increase of S.I. level. Analysis of TCR V beta repertoire of the lesion of GPP showed strong expression of V beta 14 and 16 with mild expression of V 13-2 and 19, which may suggest that TCR V beta repertoire became oligoclonal in case of complication of these two disorders. In conclusion, our data did not suggest any common immunological responses to staphylococcal enterotoxin in induction of both psoriasis and SjS.
干燥综合征（SjS）是一种自身免疫性疾病，近来有研究提示免疫机制在银屑病发病机制中起作用；然而，这两种疾病同时存在的情况相对少见。为了确定是否存在共同的潜在异常本质，对5例银屑病合并干燥综合征患者进行了研究。其中2例为寻常型银屑病（PV），2例为关节病型银屑病（PA），另1例为泛发性脓疱型银屑病（GPP）。通过³H-胸腺嘧啶核苷掺入法检测针对葡萄球菌肠毒素B的淋巴细胞反应。对1例GPP患者，采用逆转录聚合酶链反应（RT-PCR）检测皮损中浸润T细胞的T细胞受体（TCR）Vβ谱型。银屑病合并干燥综合征患者的刺激指数（S.I.）水平与单纯银屑病或干燥综合征患者相比，未显示出任何显著升高；然而，1例PV合并干燥综合征患者出现了多种血清学免疫失衡，其S.I.水平显著升高。对GPP皮损的TCR Vβ谱型分析显示，Vβ14和16表达强烈，Vβ13 - 2和19表达较弱，这可能提示在这两种疾病并发时TCR Vβ谱型呈寡克隆化。总之，我们的数据并未提示在银屑病和干燥综合征的诱发过程中，对葡萄球菌肠毒素存在任何共同的免疫反应。
