Lin Wan-Hsin, Webb Donna J
Department of Biological Sciences and Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37235, USA.
Open Neurosci J. 2009 Jan 1;3:54-66. doi: 10.2174/1874082000903020054.
Dendritic spines are actin-rich protrusions that comprise the postsynaptic sites of synapses and receive the majority of excitatory synaptic inputs in the central nervous system. These structures are central to cognitive processes, and alterations in their number, size, and morphology are associated with many neurological disorders. Although the actin cytoskeleton is thought to govern spine formation, morphology, and synaptic functions, we are only beginning to understand how modulation of actin reorganization by actin-binding proteins (ABPs) contributes to the function of dendritic spines and synapses. In this review, we discuss what is currently known about the role of ABPs in regulating the formation, morphology, motility, and plasticity of dendritic spines and synapses.
树突棘是富含肌动蛋白的突起，构成突触的突触后位点，并在中枢神经系统中接收大部分兴奋性突触输入。这些结构对于认知过程至关重要，其数量、大小和形态的改变与许多神经系统疾病有关。尽管肌动蛋白细胞骨架被认为控制着树突棘的形成、形态和突触功能，但我们才刚刚开始了解肌动蛋白结合蛋白（ABP）对肌动蛋白重组的调节如何影响树突棘和突触的功能。在这篇综述中，我们讨论了目前已知的ABP在调节树突棘和突触的形成、形态、运动性和可塑性方面的作用。
