Molecular and Cellular Pathology, The University of Queensland, University of Queensland Centre for Clinical Research (UQCCR), Royal Brisbane and Women's Hospital, Herston, Brisbane, Australia.
Histopathology. 2011 Jan;58(2):155-68. doi: 10.1111/j.1365-2559.2010.03613.x. Epub 2010 Aug 16.
This review covers aspects of adrenal cortical tumours, phaeochromocytoma and extra-adrenal paragangliomas. Relevant clinical and epidemiological information is included. It is now known that about 30% of paragangliomas occur in a familial setting and these new aspects of the genetic background are presented. The main diagnostic problem in both groups of tumours is the recognition of malignant potential. The uses and limitations of multifactorial histological assessment in diagnosis and prognosis are discussed. Finally, data on the molecular changes associated with tumorigenesis and tumour progression are highlighted, and how this information may contribute in future to diagnosis and prognosis.
本文综述了肾上腺皮质肿瘤、嗜铬细胞瘤和肾上腺外副神经节瘤的相关方面，包括了临床和流行病学的相关信息。目前已知约 30%的副神经节瘤为家族性发病，本文对其遗传背景的新方面进行了介绍。在这两组肿瘤中，主要的诊断问题是恶性潜能的识别。本文讨论了多因素组织学评估在诊断和预后中的应用和局限性。最后，本文强调了与肿瘤发生和肿瘤进展相关的分子变化，以及这些信息如何在未来有助于诊断和预后。
