Department of Veterinary Science, University of Messina, Viale Annunziata, 98168, Messina, Italy.
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Via F. Stagno D'alcontres 31, 98166, Messina, Italy.
Sci Rep. 2021 Feb 11;11(1):3638. doi: 10.1038/s41598-021-83170-8.
Gastric ulcer or peptic ulcer is a common disease worldwide. Basically, it develops when there is an imbalance between the protective and aggressive factors, especially at the luminal surface of epithelial cells. Thus, there is a constant interest in research new drugs for treatment of gastric ulcer. The snail secretion is a dense mucous, that covers the external surface of the snails, with important functions for the survival of snails. The biological proprieties of snail Helix Aspersa Muller mucus it has been known for centuries to treat human disorders in particular for skin disease. Recently the use of snail mucus has seen a worldwide increase, as a component in cosmetic product and it has been used in particular for the management of wound and skin disorders. In this study we use a murine model of ethanol intragastric administration which has been widely used to test the drugs efficacies and to explore the underlying mechanism for gastric ulcer development. The intragastric ethanol administration causes several mucosal damages and an induction of a severe inflammatory response. Our results show a significant protective effect of snail secretion filtrate in reducing macroscopic and histological lesions, as well the protective effect on mucus content, oxidative stress and inflammatory response. In conclusion this study demonstrate the protective effect of intragastrical snail secretion filtrate, in a model of ethanol-induced gastric ulcer in mice, suggesting its possible useful use in the treatment or prevention of gastric ulcer.
胃溃疡或十二指肠溃疡是一种全球性的常见疾病。基本上，当保护因素和侵袭因素之间失去平衡时，特别是在上皮细胞腔面时，就会发生这种疾病。因此，人们一直对研究治疗胃溃疡的新药感兴趣。蜗牛分泌物是一种粘稠的粘液，覆盖在蜗牛的外表面，对蜗牛的生存具有重要的功能。蜗牛 Helix Aspersa Muller 粘液的生物学特性几个世纪以来，它一直被用于治疗人类疾病，特别是皮肤病。最近，蜗牛粘液的使用在全球范围内有所增加，作为化妆品产品的一个组成部分，特别是用于管理伤口和皮肤疾病。在这项研究中，我们使用了乙醇胃内给药的小鼠模型，该模型已被广泛用于测试药物的疗效，并探索胃溃疡发展的潜在机制。胃内乙醇给药会导致多种粘膜损伤，并引发严重的炎症反应。我们的结果表明，蜗牛分泌物滤液在减少宏观和组织学损伤方面具有显著的保护作用，同时对粘液含量、氧化应激和炎症反应也具有保护作用。总之，这项研究证明了蜗牛分泌物滤液在乙醇诱导的小鼠胃溃疡模型中的保护作用，提示其在治疗或预防胃溃疡方面可能有一定的应用价值。
