Kollár J, Uhrík J, Hejj F
Institute of Experimental Medicine, University P. J. Safarik, Kosice, Czechoslovakia.
Int Angiol. 1991 Jan-Mar;10(1):34-7.
Forty one patients with ischaemic heart disease (IHD) of the age 60 +/- 12.3 years were hospitalized and treated two weeks with Curantyl (Dipyridamol) which was applied per os in a dose of 75 mg 3 times, and after another two weeks 34 of them wass applied Isoptin (Verapamil) in a dose of 40 mg 3 times daily. The heat conductivity (J.m-1, sec-1.degree C.10(-2), HC) and skin temperature (degree C, ST) were examined at the isothermic level 2 cm above the inner ankle by the apparatus Fluvograph 2 of Hartmann and Braun A. G. (BRD). The HC after Isoptin application above the left and right ankle was in 34 patients increased significantly (p less than 0.001). In patients with IHD after Curantyl application the HC and ST was significantly decreased above the left and right ankle in 9 (21.9%) and in 12 (30.0%), respectively. Curantyl could deteriorate HC and so to worsen legs ulceration healing and to point ap ischemia in patients with associated chronic postphlebitic syndrome with ulcera crurium.
41名年龄在60±12.3岁的缺血性心脏病（IHD）患者入院，用Curantyl（双嘧达莫）治疗两周，口服剂量为75毫克，每日3次，再过两周后，其中34名患者服用Isoptin（维拉帕米），剂量为40毫克，每日3次。通过Hartmann和Braun A.G.（联邦德国）的Fluvograph 2仪器在内踝上方2厘米的等温水平处检查热导率（焦耳·米⁻¹·秒⁻¹·摄氏度⁻¹·10⁻²，HC）和皮肤温度（摄氏度，ST）。在34名患者中，服用Isoptin后左右踝上方的HC显著升高（p<0.001）。在IHD患者中，服用Curantyl后，左右踝上方的HC和ST分别在9名（21.9%）和12名（30.0%）患者中显著降低。Curantyl可能会使HC恶化，从而使腿部溃疡愈合变差，并指出伴有慢性静脉炎后综合征合并小腿溃疡的患者存在缺血情况。
