Department of Animal Science, Milan University, Milan, Italy.
J Appl Genet. 2010;51(3):319-21. doi: 10.1007/BF03208861.
R-spondins constitute a recently discovered small family of growth factors, and the evidence of their role in several developmental pathways is growing fast. In this work we describe the chromosomal location of the four RSPO genes in the donkey. Using horse BACs, we localized RSPO1 on EAS 5q23, RSPO2 on EAS 12q13, RSPO3 on EAS 24q26, and RSPO4 on EAS 15p13. Moreover, RSPO2, RSPO3, and RSPO4 are the first genes mapped on donkey chromosomes 12, 24, and 15, respectively.
RSP 蛋白构成一个最近发现的小的生长因子家族，它们在多个发育途径中的作用的证据正在迅速增加。在这项工作中，我们描述了驴中四个 RSPO 基因的染色体定位。使用马 BAC，我们将 RSPO1 定位在 EAS 5q23 上，RSPO2 定位在 EAS 12q13 上，RSPO3 定位在 EAS 24q26 上，RSPO4 定位在 EAS 15p13 上。此外，RSPO2、RSPO3 和 RSPO4 分别是首次定位在驴染色体 12、24 和 15 上的基因。
