Shinton R, Shipley M, Rose G
Department of Medicine, University of Birmingham, United Kingdom.
J Epidemiol Community Health. 1991 Jun;45(2):138-42. doi: 10.1136/jech.45.2.138.
The aim was to examine the risk of increasing overweight for death from stroke.
This was a prospective cohort study, in which the main outcome measure was the mortality ratio for stroke with increasing body mass index.
Civil service departments, Whitehall, London.
Participants were 17,753 men aged 40 to 64 years.
208 stroke deaths were recorded. Men aged 40 to 54 in the most overweight quintile of body mass index had a mortality ratio of 2.01 (95% confidence interval 0.9 to 4.7) compared to the thinnest quintile. The mortality ratio was 1.19 (95% CI 0.7 to 2.0) in men aged 55 to 64. The increase in risk was more apparent in non-smokers: age adjusted mortality ratio 2.58 (95% CI 1.2 to 5.7). When smoking status and overweight were considered in combination a gradient of the age adjusted mortality ratio was observed, from 1.0 in thinner/non-smokers up to 3.15 in fatter/current smokers. On the assumption that smoking and obesity cause strokes, an estimated 60% of strokes could be prevented if these two easily identifiable risk factors could be avoided.
The risks of overweight for death from stroke were more apparent in younger subjects and non-smokers. A substantial proportion of stroke deaths occurring under the age of 80 years would probably be prevented if cigarette smoking and overweight could be avoided.
旨在研究超重增加中风死亡风险的情况。
这是一项前瞻性队列研究，主要结局指标是随着体重指数增加中风的死亡率。
伦敦白厅的公务员部门。
17753名年龄在40至64岁之间的男性。
记录到208例中风死亡病例。体重指数处于最超重五分位数的40至54岁男性，与最瘦五分位数的男性相比，死亡率为2.01（95%置信区间0.9至4.7）。55至64岁男性的死亡率为1.19（95%置信区间0.7至2.0）。在不吸烟者中风险增加更为明显：年龄调整后的死亡率为2.58（95%置信区间1.2至5.7）。当综合考虑吸烟状况和超重情况时，观察到年龄调整后死亡率呈梯度变化，从较瘦/不吸烟者的1.0到较胖/当前吸烟者的3.15。假设吸烟和肥胖会导致中风，如果能避免这两个易于识别的风险因素，估计60%的中风可以预防。
超重导致中风死亡的风险在年轻受试者和不吸烟者中更为明显。如果能避免吸烟和超重，可能会预防很大一部分80岁以下发生的中风死亡。
