Ventre J, Vighetto A, Bailly G, Prablanc C
Vision et Motricité INSERM U.94, Bron, France.
J Neurol Sci. 1991 Apr;102(2):144-9. doi: 10.1016/0022-510x(91)90062-c.
We studied the parameters (latency, amplitude, peak velocity) of horizontal saccades in 32 patients with multiple sclerosis (MS) and 20 healthy, age matched control subjects. Saccades were recorded by direct-current electro-oculography technique (EOG). The patients were divided in 2 groups according to the absence or the presence of clinical internuclear ophthalmoplegia (INO). In both groups, we found increased latency, hypometria and reduced velocity. The disconjugacy of saccades was measured by calculating the ratio of abduction and adduction peak velocities (the versional disconjugacy index: VDI). Though the absolute value of this index might be dependent on the recording technique, its variation is not. Interestingly, the VDI was significantly increased in the groups of MS patients without clinical INO, indicating a more severe slowing in adduction. We concluded that VDI may be a very useful index in detecting subtle disorders in saccades conjugacy.
我们研究了32例多发性硬化症（MS）患者和20名年龄匹配的健康对照者水平扫视的参数（潜伏期、幅度、峰值速度）。通过直流眼电图技术（EOG）记录扫视。根据是否存在临床核间性眼肌麻痹（INO）将患者分为两组。在两组中，我们均发现潜伏期延长、眼动范围减小和速度降低。通过计算外展和内收峰值速度的比值（版本失调指数：VDI）来测量扫视的非共轭性。尽管该指数的绝对值可能取决于记录技术，但其变化并非如此。有趣的是，在无临床INO的MS患者组中VDI显著升高，表明内收减慢更为严重。我们得出结论，VDI可能是检测扫视共轭性细微障碍的非常有用的指标。
