Department of Molecular and Medical Pharmacology, Molecular Biology Institute, 650 Charles E. Young Drive, Los Angeles, CA 90095, USA.
Immunol Res. 2010 Dec;48(1-3):14-26. doi: 10.1007/s12026-010-8164-z.
An early and critical event of the human immunodeficiency virus type 1 (HIV-1) life cycle is uncoating of the viral core. Uncoating involves the disassembly of HIV-1 capsid (CA). The underlying mechanisms governing uncoating are poorly defined, and the role of viral and host factors in uncoating is not well understood. Cyclophilin A and TRIM5α are two cellular factors that interact with CA in exerting their effects on HIV-1 replication. Here, we review the current understanding of uncoating and the new functional role of HIV-1 IN during uncoating.
人类免疫缺陷病毒 1 型（HIV-1）生命周期中的一个早期且关键的事件是病毒核心的脱壳。脱壳涉及 HIV-1 衣壳（CA）的解体。脱壳的潜在机制尚未明确，病毒和宿主因素在脱壳中的作用也尚未完全理解。亲环素 A 和 TRIM5α 是两种与 CA 相互作用以发挥其对 HIV-1 复制作用的细胞因子。本文综述了目前对脱壳的理解以及 HIV-1 IN 在脱壳过程中的新功能作用。
