Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Flanders, Belgium.
Viruses. 2021 May 4;13(5):829. doi: 10.3390/v13050829.
The HIV replication cycle depends on the interaction of viral proteins with proteins of the host. Unraveling host-pathogen interactions during the infection is of great importance for understanding the pathogenesis and the development of antiviral therapies. To date HIV uncoating and nuclear import are the most debated steps of the HIV-1 replication cycle. Despite numerous studies during past decades, there is still much controversy with respect to the identity and the role of viral and host factors involved in these processes. In this review, we provide a comprehensive overview on the role of transportin-SR2 as a host cell factor during active nuclear transport.
HIV 复制周期依赖于病毒蛋白与宿主蛋白的相互作用。解析感染过程中的宿主-病原体相互作用对于理解发病机制和开发抗病毒疗法非常重要。迄今为止，HIV 脱壳和核输入是 HIV-1 复制周期中最具争议的步骤。尽管在过去几十年中进行了大量研究，但对于涉及这些过程的病毒和宿主因子的身份和作用仍存在许多争议。在这篇综述中，我们全面概述了转运蛋白-SR2 在活跃核转运过程中作为宿主细胞因子的作用。
