Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
Basic Clin Pharmacol Toxicol. 2011 Jan;108(1):34-9. doi: 10.1111/j.1742-7843.2010.00622.x. Epub 2010 Aug 16.
Eucalyptol, also known as 1,8-cineole, is a monoterpene traditionally used to treat respiratory disorders due to its secretolytic properties. In addition to its myorelaxant effects, it also has anti-inflammatory actions in vitro. In this study, we aimed to evaluate the efficacy of acute treatment with 1,8-cineole on reducing airway inflammatory parameters. Ovalbumin (OVA)-sensitized guinea pigs were submitted to antigenic challenge (OVA) with or without pre-treatment with a single dose of 1,8-cineole administered by inhalation. Airway inflammatory parameters were reduced or absent in 1,8-cineole-treated animals as compared with untreated guinea pigs. Acute treatment with 1,8-cineole impaired the development of airway hyperresponsiveness to carbachol in isolated tracheal rings. Levels of the pro-inflammatory cytokines TNFα and IL-1β was lower in bronchoalveolar lavage fluid (BALF) of 1,8-cineol-treated guinea pigs than in untreated animals. 1,8-Cineole impaired the OVA-induced increase of the myeloperoxidase activity in BALF. 1,8-Cineole also prevented the reduction of the mucociliary clearance induced by the antigen presentation. The present investigation provides evidence that inhaled 1,8-cineole prevents hyperresponsiveness and inhibits inflammation in airways of ovalbumin-challenged guinea pigs.
桉油醇，也称为 1,8-桉叶素，是一种单萜类化合物，传统上用于治疗呼吸道疾病，因为它具有分泌溶解特性。除了具有肌肉松弛作用外，它在体外还具有抗炎作用。在这项研究中，我们旨在评估急性治疗 1,8-桉叶醇对降低气道炎症参数的功效。卵清蛋白（OVA）致敏豚鼠接受抗原挑战（OVA），或在单次吸入 1,8-桉叶醇预处理后接受抗原挑战。与未治疗的豚鼠相比，1,8-桉叶醇治疗的动物气道炎症参数减少或消失。急性治疗 1,8-桉叶醇可损害分离的气管环对乙酰胆碱引起的气道高反应性的发展。1,8-桉叶醇处理的豚鼠支气管肺泡灌洗液（BALF）中的促炎细胞因子 TNFα 和 IL-1β 水平低于未处理的动物。1,8-桉叶醇可抑制 BALF 中卵清蛋白诱导的髓过氧化物酶活性增加。1,8-桉叶醇还可防止抗原呈递引起的黏液清除率降低。本研究提供的证据表明，吸入 1,8-桉叶醇可预防卵清蛋白挑战豚鼠的气道高反应性和抑制炎症。
