Pries Ralph, Jeschke Stephanie, Leichtle Anke, Bruchhage Karl-Ludwig
Department of Otorhinolaryngology, University of Luebeck, 23538 Luebeck, Germany.
Metabolites. 2023 Jun 13;13(6):751. doi: 10.3390/metabo13060751.
The monoterpene 1,8-Cineol is a natural plant-based therapeutic agent that is commonly applied to treat different inflammatory diseases due to its mucolytic, anti-microbial and anti-inflammatory properties. It has become increasingly clear in the recent years that 1,8-Cineol spreads almost everywhere in the human body after its oral administration, from the gut to the blood to the brain. Its anti-microbial potential and even its anti-viral effects have been observed to include numerous bacteria and fungi species. Many recent studies help to better understand the cellular and molecular immunological consequences of 1,8-Cineol treatment in inflammatory diseases and further provide information concerning the mechanistic modes of action in the regulation of distinct inflammatory biosynthetic pathways. This review aims to present a holistic and understandable overview of the different aspects of 1,8-Cineol in infections and inflammation.
单萜类化合物1,8-桉叶素是一种天然的植物性治疗剂，因其具有粘液溶解、抗菌和抗炎特性，常用于治疗各种炎症性疾病。近年来越来越清楚的是，1,8-桉叶素口服后几乎能在人体各处扩散，从肠道到血液再到大脑。已观察到其抗菌潜力甚至抗病毒作用涵盖多种细菌和真菌物种。最近的许多研究有助于更好地理解1,8-桉叶素治疗炎症性疾病的细胞和分子免疫学后果，并进一步提供有关调节不同炎症生物合成途径的作用机制模式的信息。本综述旨在全面且通俗易懂地概述1,8-桉叶素在感染和炎症方面的不同情况。
