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哪些人参加了英国的糖尿病筛查项目?ADDITION-Cambridge 研究的结果。

Who attends a UK diabetes screening programme? Findings from the ADDITION-Cambridge study.

机构信息

MRC Epidemiology Unit, Cambridge, UK.

出版信息

Diabet Med. 2010 Sep;27(9):995-1003. doi: 10.1111/j.1464-5491.2010.03056.x.

Abstract

AIMS

One of the factors influencing the cost-effectiveness of population screening for Type 2 diabetes may be uptake. We examined attendance and practice- and individual-level factors influencing uptake at each stage of a diabetes screening programme in general practice.

METHODS

A stepwise screening programme was undertaken among 135, 825 people aged 40-69 years without known diabetes in 49 general practices in East England. The programme included a score based on routinely available data (age, sex, body mass index and prescribed medication) to identify those at high risk, who were offered random capillary blood glucose (RBG) and glycosylated haemoglobin tests. Those screening positive were offered fasting capillary blood glucose (FBG) and confirmatory oral glucose tolerance tests (OGTT).

RESULTS

There were 33 539 high-risk individuals invited for a RBG screening test; 24 654 (74%) attended. Ninety-four per cent attended the follow-up FBG test and 82% the diagnostic OGTT. Seventy per cent of individuals completed the screening programme. Practices with higher general practitioner staff complements and those located in more deprived areas had lower uptake for RBG and FBG tests. Male sex and a higher body mass index were associated with lower attendance for RBG testing. Older age, prescription of antihypertensive medication and a higher risk score were associated with higher attendance for FBG and RBG tests.

CONCLUSIONS

High attendance rates can be achieved by targeted stepwise screening of individuals assessed as high risk by data routinely available in general practice. Different strategies may be required to increase initial attendance, ensure completion of the screening programme, and reduce the risk that screening increases health inequalities.

摘要

目的

影响 2 型糖尿病人群筛查成本效益的因素之一可能是参与度。我们研究了在一般实践中的糖尿病筛查计划的每个阶段,出勤率以及实践和个体水平因素对参与度的影响。

方法

在英格兰东部的 49 家普通实践中,对 135825 名年龄在 40-69 岁之间、无已知糖尿病的人群进行了逐步筛查计划。该计划包括了基于常规可用数据(年龄、性别、体重指数和规定药物)的评分,以确定那些高风险的人群,他们被提供随机毛细血管血糖(RBG)和糖化血红蛋白测试。那些筛查阳性的人被提供空腹毛细血管血糖(FBG)和确认口服葡萄糖耐量试验(OGTT)。

结果

有 33539 名高风险个体被邀请进行 RBG 筛查测试;24654 人(74%)参加。94%的人参加了后续的 FBG 测试,82%的人参加了诊断 OGTT。70%的人完成了筛查计划。普通医生人员配备更高的实践和位于更贫困地区的实践,RBG 和 FBG 测试的参与率较低。男性和更高的体重指数与 RBG 测试的出勤率较低相关。年龄较大、服用抗高血压药物和更高的风险评分与 FBG 和 RBG 测试的出勤率较高相关。

结论

通过对通过普通实践中常规可用数据评估为高风险的个体进行有针对性的逐步筛查,可以实现高出勤率。可能需要不同的策略来提高初始出勤率、确保完成筛查计划,并降低筛查增加健康不平等的风险。

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Screening for type 2 diabetes: literature review and economic modelling.2型糖尿病筛查:文献综述与经济建模
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