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全球糖尿病肾病负担:时间趋势和性别差距。

The Global Burden of Diabetic Kidney Disease: Time Trends and Gender Gaps.

机构信息

Department of Global Health, University of Washington, 325 9th Avenue (Box 359931), Seattle, WA, 98104, USA.

出版信息

Curr Diab Rep. 2019 Mar 2;19(4):18. doi: 10.1007/s11892-019-1133-6.

DOI:10.1007/s11892-019-1133-6
PMID:30826889
Abstract

PURPOSE OF REVIEW

Diabetes mellitus prevalence is increasing throughout the world as a consequence of growing rates of obesity, metabolic syndrome, and westernization of lifestyle. It is currently unknown to what extent these trends affect the global burden of diabetic kidney disease (DKD). This review seeks to describe the global burden of DKD and how it has changed throughout time using recently released results of the Global Burden of Disease 2017 Study.

RECENT FINDINGS

DKD prevalence has remained fairly stable at the global level and among many world regions since 1990. At the global level, the proportion of DKD deaths relative to other types of CKD is increasing. Certain world regions still have very high rates of DKD, whereas other world regions have decreasing prevalence and mortality. Screening will likely play an important role in mitigating the growing burden within high-risk regions.

摘要

目的综述

随着肥胖症、代谢综合征和生活方式西化发生率的增加,糖尿病的患病率在全球范围内不断上升。目前尚不清楚这些趋势在何种程度上影响了全球糖尿病肾病(DKD)的负担。本综述旨在描述 DKD 的全球负担,以及使用最近发布的 2017 年全球疾病负担研究结果,了解其随时间的变化情况。

最新发现

自 1990 年以来,DKD 的全球患病率和世界许多地区的患病率基本保持稳定。在全球范围内,DKD 死亡比例相对于其他类型的慢性肾脏病(CKD)呈上升趋势。某些世界区域的 DKD 发病率仍然很高,而其他世界区域的患病率和死亡率呈下降趋势。筛查可能在减轻高风险地区日益增长的负担方面发挥重要作用。

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The Mitochondrial Metabolism Gene ECH1 Was Identified as a Novel Biomarker for Diabetic Nephropathy: Using Bioinformatics Analysis and Experimental Confirmation.线粒体代谢基因ECH1被鉴定为糖尿病肾病的新型生物标志物:基于生物信息学分析和实验验证
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