Centre for Nanotechnology & Regenerative Medicine, Division of Surgery & Interventional Science, University College London, London, UK.
Trends Biotechnol. 2010 Nov;28(11):580-8. doi: 10.1016/j.tibtech.2010.07.006. Epub 2010 Aug 18.
Nanosilver (NS), comprising silver nanoparticles, is attracting interest for a range of biomedical applications owing to its potent antibacterial activity. It has recently been demonstrated that NS has useful anti-inflammatory effects and improves wound healing, which could be exploited in developing better dressings for wounds and burns. The key to its broad-acting and potent antibacterial activity is the multifaceted mechanism by which NS acts on microbes. This is utilized in antibacterial coatings on medical devices to reduce nosocomial infection rates. Many new synthesis methods have emerged and are being evaluated for NS production for medical applications. NS toxicity is also critically discussed to reflect on potential concerns before widespread application in the medical field.
纳米银（NS）由银纳米粒子组成，由于其强大的抗菌活性，正引起人们对一系列生物医学应用的兴趣。最近已经证明，NS 具有有用的抗炎作用，并能促进伤口愈合，这可以用来开发更好的伤口和烧伤敷料。其广谱和强大的抗菌活性的关键是 NS 作用于微生物的多方面机制。这一机制被用于医疗器械的抗菌涂层，以降低医院感染率。许多新的合成方法已经出现，并正在评估其用于医疗应用的 NS 生产。NS 的毒性也受到了严格的讨论，以反映在广泛应用于医疗领域之前的潜在问题。
