Rosen Dennis
Children's Hospital Boston, Harvard Medical School, MA, USA.
Clin Pediatr (Phila). 2010 Nov;49(11):1068-71. doi: 10.1177/0009922810378037. Epub 2010 Aug 19.
Obstructive sleep apnea (OSA) is commonly seen in children with Down syndrome (DS). Though some infants with DS spontaneously outgrow their OSA, it is not clear how often this occurs or how this should affect the choice between surgical and nonsurgical treatment.
Retrospective chart review of all infants with DS younger than 2 years referred over a 66-month period to Children's Hospital Boston for sleep study because of suspected OSA.
A total of 16 of 29 children studied were diagnosed with OSA; 6 were treated with continuous positive airway pressure (CPAP), 3 of whom were found 5, 5, and 10 months later on repeat sleep study to have no further evidence of OSA.
A significant number of infants with DS and OSA may outgrow it within several months. This has implications for treatment choice, especially between CPAP and tracheostomy, because it may only be needed for a short time.
阻塞性睡眠呼吸暂停（OSA）在唐氏综合征（DS）患儿中很常见。虽然一些患有DS的婴儿会自然摆脱OSA，但不清楚这种情况发生的频率以及这应如何影响手术治疗和非手术治疗之间的选择。
回顾性分析66个月期间因疑似OSA转诊至波士顿儿童医院进行睡眠研究的所有2岁以下DS婴儿的病历。
29名接受研究的儿童中，共有16名被诊断为OSA；6名接受持续气道正压通气（CPAP）治疗，其中3名在5、5和10个月后重复睡眠研究时未发现有OSA的进一步证据。
相当数量患有DS和OSA的婴儿可能在几个月内自然摆脱该病。这对治疗选择有影响，尤其是在CPAP和气管造口术之间，因为可能只需要短时间使用。
