Departamento de Microbiología, Universidad de Granada, Granada, Spain.
Laboratorio de Microbiología, Hospital Universitario Virgen de las Nieves, Granada, Spain.
J Med Microbiol. 2010 Nov;59(Pt 11):1267-1274. doi: 10.1099/jmm.0.020362-0. Epub 2010 Aug 19.
Chlamydia pneumoniae is an obligate intracellular human pathogen responsible for a wide range of acute and chronic human diseases, including pneumonia and other respiratory diseases. Serological methods for the diagnosis of C. pneumoniae infection vary widely, and several authors have reported significant inter- and intra-laboratory variability in diagnostic methods and criteria. Over the past 10 years, numerous studies have focused on the identification of specific antigens for application in serodiagnosis, including the diagnosis of persistent infections. The use of proteomics may enable the development of serological diagnosis kits that offer reliable sensitivity and specificity and might even differentiate between the various stages of infection with this pathogen.
肺炎衣原体是一种专性细胞内人类病原体，可导致多种急性和慢性人类疾病，包括肺炎和其他呼吸道疾病。用于诊断肺炎衣原体感染的血清学方法差异很大，一些作者报告说，诊断方法和标准在实验室间和实验室内部存在显著差异。在过去的 10 年中，许多研究都集中在鉴定用于血清学诊断的特定抗原上，包括持续性感染的诊断。蛋白质组学的应用可能会开发出具有可靠灵敏度和特异性的血清学诊断试剂盒，甚至可以区分该病原体感染的各个阶段。
