Hidayat Rudy, Setiati Siti, Soewondo Pradana
Department of Internal Medicine, Faculty of Medicine, University of Indonesia - Cipto Mangunkusumo Hospital, Jl. Diponegoro no. 71, Jakarta Pusat 10430, Indonesia.
Acta Med Indones. 2010 Jul;42(3):123-9.
to identify the association between vitamin D deficiency and type-2 diabetes mellitus in elderly population.
a study was conducted at the geriatric clinic of Cipto Mangunkusumo Hospital in November 2007, with a cross-sectional design. The accessible population of our study were patients with type-2 diabetes mellitus and non-diabetes mellitus patients who visited the clinic for treatment. The subject criteria were: patients >60 years old with operational definition of type-2 diabetes mellitus, and willing to participate in the study. Data collected included characteristics, such as age, sex, education level, history of family illness, frequency of outdoor activity, duration of direct sun exposure in their outdoor activities, history of using sun protector; and the laboratory data such as 25(OH)D3 serum level, calcium and albumin serum level. Data analysis was done by Chi-Square test and multivariate analysis was performed by logistic regression technique to control some identified confounding factors. All data processing and statistical analyses were done with SPSS 11.5 for windows.
we found a total number of 78 subjects. Of them, 40 subjects were with DM, and 38 subjects without DM. Most subjects were female (66.7%), and obese (44.9%). Direct sun exposure of most subjects was indicated by the frequency of outdoor activity of more than 3 times a week (74.4%). Duration of exposure in most subjects was less than 15 minutes (43.6%), with application of sun protector agent (56.4%). The prevalence of vitamin D deficiency was 78.2%, with a cut-off of <50 nmol/L.
sex, BMI and the use of sun protectors proven as variables are associated with vitamin D deficiency. The association between vitamin D deficiency and type-2 diabetes mellitus cannot be proven statistically in our study (p=0.482; OR=0.8; CI=0.5-1.3).
确定老年人群中维生素D缺乏与2型糖尿病之间的关联。
2007年11月在西托·曼古库苏莫医院老年诊所进行了一项研究，采用横断面设计。本研究的可及人群为前来诊所治疗的2型糖尿病患者和非糖尿病患者。受试者标准为：年龄>60岁，符合2型糖尿病的操作定义，且愿意参与研究。收集的数据包括特征，如年龄、性别、教育水平、家族病史、户外活动频率、户外活动中直接日晒时间、使用防晒剂的历史；以及实验室数据，如25(OH)D3血清水平、钙和白蛋白血清水平。数据分析采用卡方检验，多变量分析采用逻辑回归技术以控制一些已确定的混杂因素。所有数据处理和统计分析均使用SPSS 11.5 for windows完成。
我们共发现78名受试者。其中，40名受试者患有糖尿病，38名受试者未患糖尿病。大多数受试者为女性(66.7%)，且肥胖(44.9%)。大多数受试者的直接日晒情况通过每周户外活动超过3次的频率来表明(74.4%)。大多数受试者的暴露时间少于15分钟(43.6%)，使用了防晒剂(56.4%)。维生素D缺乏的患病率为78.2%，临界值为<50 nmol/L。
已证实性别、体重指数和使用防晒剂这些变量与维生素D缺乏有关。在我们的研究中，维生素D缺乏与2型糖尿病之间的关联无法通过统计学方法得到证实(p = 0.482；OR = 0.8；CI = 0.5 - 1.3)。
