Department of Pathology and Microbiology, Aga Khan University Hospital (AKUH), Karachi, Pakistan.
Clin Biochem. 2010 Dec;43(18):1431-5. doi: 10.1016/j.clinbiochem.2010.09.022. Epub 2010 Sep 27.
This study aims to determine the prevalence and significance of vitamin D deficiency and insufficiency among apparently healthy adults.
A total of 123 subjects, 56.9% males and 43.1% females, were recruited from a tertiary care hospital in Karachi, Pakistan. Questionnaires were administered to gather demographics; height, weight, and blood samples were also taken. For staging serum 25OHD, the cutoff values ≤50 nmol/L and 50.1-74.9 nmol/L were defined as deficiency and insufficiency, respectively.
The mean vitamin D level in the study subjects was 41.1±9.6 nmol/L. Of them, 90% had low serum 25OHD levels: 69.9% were deficient and 21.1% had insufficient levels of 25OHD. There was a significant negative correlation between serum 25OHD and iPTH levels.
The high prevalence of vitamin D deficiency and insufficiency showed that a high proportion of apparently healthy adults are at risk of developing musculoskeletal and other chronic diseases. Serum iPTH and serum 25OHD levels are better markers of this deficiency as compared to other markers.
本研究旨在确定维生素 D 缺乏和不足在貌似健康的成年人中的流行程度和意义。
从巴基斯坦卡拉奇的一家三级保健医院招募了 123 名受试者，其中 56.9%为男性，43.1%为女性。通过问卷调查收集人口统计学资料；同时还采集了身高、体重和血液样本。为了对血清 25OHD 进行分期，将 ≤50 nmol/L 和 50.1-74.9 nmol/L 的截断值分别定义为缺乏和不足。
研究对象的平均维生素 D 水平为 41.1±9.6 nmol/L。其中，90%的人血清 25OHD 水平较低：69.9%为缺乏，21.1%为 25OHD 不足。血清 25OHD 与 iPTH 水平之间存在显著的负相关关系。
维生素 D 缺乏和不足的高患病率表明，相当一部分貌似健康的成年人面临发生肌肉骨骼和其他慢性疾病的风险。与其他标志物相比，血清 iPTH 和血清 25OHD 水平是这种缺乏的更好标志物。
