揭示 PINK1 和 parkin 在自噬中的作用。
Uncovering the roles of PINK1 and parkin in mitophagy.
机构信息
Protein metabolism project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan.
出版信息
Autophagy. 2010 Oct;6(7):952-4. doi: 10.4161/auto.6.7.13039. Epub 2010 Oct 16.
Abstract
Parkinson disease (PD) is the second most prevalent neurodegenerative disorder, and thus elucidation of the pathogenic mechanism and establishment of a fundamental cure is essential in terms of public welfare. Fortunately, our understanding of the pathogenesis of two types of recessive familial PDs--early-onset familial PD caused by dysfunction of the PTEN induced putative kinase 1 (PINK1) gene and autosomal recessive juvenile Parkinsonism (ARJP) caused by a mutation in the Parkin gene--has evolved and continues to expand.
摘要
帕金森病（PD）是第二大常见的神经退行性疾病，因此，从公益的角度来看，阐明其发病机制并建立根本的治疗方法至关重要。幸运的是，我们对两种隐性家族性 PD 的发病机制的理解--由 PTEN 诱导的假定激酶 1（PINK1）基因突变引起的早发性家族性 PD 和由 Parkin 基因突变引起的常染色体隐性青少年帕金森病（ARJP）--已经发展并在不断扩展。
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本文引用的文献
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