小鼠中枢神经系统中Gb(3)免疫反应性的分布
Distribution of Gb(3) Immunoreactivity in the Mouse Central Nervous System.
作者信息
Obata Fumiko, Obrig Tom
机构信息
Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 W. Baltimore St. HSFI suite 380, Baltimore, MD 21201, USA.
出版信息
Toxins (Basel). 2010 Aug;2(8):1997-2006. doi: 10.3390/toxins2081997.
We have shown previously that neurons in the mouse spinal cord express Gb(3). We show in this article that distribution of anti-Gb(3)-Ab reactivity occurs in many different types of neurons of different areas of the central nervous system (CNS). The immunoreactive neurons are in olfactory bulbs, cerebral cortex, hippocampus, striatum, amygdala, thalamus, hypothalamus, cerebellum, and medulla oblongata. In several different circumventricular organs where vessels do not have the blood-brain-barrier (BBB) structure, anti-Gb(3)-Ab is not positive for vessel structures, while neurons at these regions are positive. Also, within the ventricular area, ependymal cells in the third ventricle express Gb(3), as revealed by anti-Gb(3)-Ab staining and intensity analysis.
我们之前已经表明，小鼠脊髓中的神经元表达Gb(3)。我们在本文中表明，抗Gb(3)抗体反应性的分布出现在中枢神经系统（CNS）不同区域的许多不同类型的神经元中。免疫反应性神经元存在于嗅球、大脑皮层、海马体、纹状体、杏仁核、丘脑、下丘脑、小脑和延髓中。在几个不同的室周器官中，血管没有血脑屏障（BBB）结构，抗Gb(3)抗体对血管结构呈阴性，而这些区域的神经元呈阳性。此外，在脑室区域内，抗Gb(3)抗体染色和强度分析显示，第三脑室的室管膜细胞表达Gb(3)。
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