Collins Ashley, Nasir Adnan
J Clin Aesthet Dermatol. 2010 Mar;3(3):35-9.
Nanotechnology is a rapidly growing discipline that capitalizes on the unique properties of matter engineered on the nanoscale. Vehicles incorporating nanotechnology have led to great strides in drug delivery, allowing for increased active ingredient stability, bioavailability, and site-specific targeting. Botulinum toxin has historically been used for the correction of neurological and neuromuscular disorders, such as torticollis, blepharospasm, and strabismus. Recent dermatological indications have been for the management of axillary hyperhydrosis and facial rhytides. Traditional methods of botulinum toxin delivery have been needle-based. These have been associated with increased pain and cost. Newer methods of botulinum toxin formulation have yielded topical preparations that are bioactive in small pilot clinical studies. While there are some risks associated with topical delivery, the refinement and standardization of delivery systems and techniques for the topical administration of botulinum toxin using nanotechnology is anticipated in the near future.
纳米技术是一门迅速发展的学科，它利用在纳米尺度上设计的物质的独特性质。包含纳米技术的载体在药物递送方面取得了巨大进展，提高了活性成分的稳定性、生物利用度，并实现了位点特异性靶向。肉毒杆菌毒素一直以来被用于治疗神经和神经肌肉疾病，如斜颈、眼睑痉挛和斜视。最近在皮肤科领域的应用是治疗腋窝多汗症和面部皱纹。传统的肉毒杆菌毒素递送方法是基于针头的。这些方法伴随着疼痛加剧和成本增加的问题。新型肉毒杆菌毒素制剂已产生了在小型先导临床研究中具有生物活性的局部用制剂。虽然局部递送存在一些风险，但预计在不久的将来，利用纳米技术进行肉毒杆菌毒素局部给药的递送系统和技术将得到改进和标准化。
