Department of Mechanical Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
J Biomed Mater Res A. 2010 Nov;95(2):588-99. doi: 10.1002/jbm.a.32862.
Percutaneous orthopedic and dental implants require not only good adhesion with bone but also the ability to attach and form seals with connective tissues and the skin. To solve the skin-seal problem of such implants, an electrochemical deposition method was used to modify the surfaces of metallic implants to improve their antibacterial ability and skin seals around them. A dense and uniform fluoridated calcium phosphate coating with a thickness of about 200 nm was deposited on an acid-etched pure titanium substrate by controlling the current density and reaction duration of the electrochemical process. The as-deposited amorphous fluoridated calcium phosphate transformed to fluoridated hydroxyapatite (FHA) after heat treatment at 600°C in a water vapor environment for 3 h. Both single crystal diffraction patterns and high-resolution transmission electron microscope (HRTEM) images confirmed the phase of the fluoridated calcium phosphate after the heat treatment. The antibacterial activities of FHA coatings were tested against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and Porphyromonas gingivalis (P. gingivalis) with the film attachment method. The antibacterial activity of FHA coating is much higher than that of pure hydroxyapatite (HA) coating and acid-etched pure titanium surface. The promising features of FHA coating make it suitable for orthopedic and dental applications.
经皮骨科和牙科植入物不仅需要与骨骼有良好的附着力，还需要能够与结缔组织和皮肤附着并形成密封。为了解决此类植入物的皮肤密封问题，采用电化学沉积方法来修饰金属植入物的表面，以提高其抗菌能力和周围皮肤的密封性。通过控制电化学过程的电流密度和反应时间，在酸蚀纯钛基底上沉积了一层约 200nm 厚的致密且均匀的氟化钙磷涂层。在水蒸气环境中于 600°C 下进行 3 小时的热处理后，沉积的非晶氟化钙磷转化为氟化羟基磷灰石（FHA）。单晶衍射图谱和高分辨率透射电子显微镜（HRTEM）图像均证实了热处理后氟化钙磷的相。采用薄膜附着法测试 FHA 涂层对金黄色葡萄球菌（S. aureus）、大肠杆菌（E. coli）和牙龈卟啉单胞菌（P. gingivalis）的抗菌活性。FHA 涂层的抗菌活性明显高于纯羟基磷灰石（HA）涂层和酸蚀纯钛表面。FHA 涂层具有广阔的应用前景，适合用于骨科和牙科。
