Department of Orthopaedics and Traumatology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
J Orthop Res. 2011 Jan;29(1):138-42. doi: 10.1002/jor.21204. Epub 2010 Aug 19.
The aim of this study was to evaluate the effect of strontium ranelate (SrR) on fracture healing in the osteoporotic rat model. Forty female Sprague-Dawley rats aged 3 months were enrolled in the study. Osteoporosis was induced by bilateral ovariectomy and subsequent daily heparin injection started 1 week after surgery and lasted for 4 weeks. Osteoporosis was confirmed by a reduction of bone mineral density (BMD). Twenty of the osteoporotic rats were assigned to the SrR group and the remaining 20 to the control group. An open right tibial midshaft transverse fracture was created and then an intramedullary fixation was performed. SrR group was treated by 450 mg/kg/day SrR per oral. Six weeks after surgical induction of fracture, all animals were sacrificed. One animal from each group died after ovariectomy. Two tibiae from the control group failed to unite. SrR-treated group showed higher mechanical strength and fracture stiffness when compared to the control group (p = 0.006, p = 0.001, respectively). SrR-treated group had mature woven bone or predominantly woven bone compared with osteoporotic control group (p = 0.038). SrR-treated group's callus maturity was significantly higher than control group (p = 0.001). SrR is associated with better fracture healing in the osteoporotic rat model.
本研究旨在评估雷奈酸锶（SrR）对骨质疏松症大鼠模型骨折愈合的影响。将 40 只 3 月龄雌性 Sprague-Dawley 大鼠纳入研究。通过双侧卵巢切除术和随后的每日肝素注射诱导骨质疏松症，手术 1 周后开始注射，持续 4 周。通过骨密度（BMD）降低来确认骨质疏松症。20 只骨质疏松症大鼠被分配到 SrR 组，其余 20 只分到对照组。通过开放右侧胫骨中段横断骨折并进行髓内固定来创建骨折。SrR 组通过口服 450mg/kg/天 SrR 进行治疗。骨折手术后 6 周，所有动物均被处死。每组中都有一只动物在卵巢切除术后死亡。对照组中有两只胫骨未能愈合。与对照组相比，SrR 治疗组的机械强度和骨折刚度更高（p = 0.006，p = 0.001）。与骨质疏松症对照组相比，SrR 治疗组的成熟编织骨或主要编织骨更多（p = 0.038）。SrR 治疗组的骨痂成熟度明显高于对照组（p = 0.001）。SrR 与骨质疏松症大鼠模型中更好的骨折愈合有关。
