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促进骨折愈合的综合方法：外用中草药膏联合口服雷奈酸锶

Integrative Approach to Facilitate Fracture Healing: Topical Chinese Herbal Paste with Oral Strontium Ranelate.

作者信息

Siu Wing-Sum, Shiu Hoi-Ting, Ko Chun-Hay, Shum Wai-Ting, Yu Ho-Nam, Lau Clara Bik-San, Hung Leung-Kim, Leung Ping-Chung

机构信息

Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

出版信息

Evid Based Complement Alternat Med. 2017;2017:9795806. doi: 10.1155/2017/9795806. Epub 2017 Dec 31.

DOI:10.1155/2017/9795806
PMID:29456575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5804400/
Abstract

Strontium ranelate (SrR) is one of the pharmaceutical agents reported to be effective on the promotion of fracture healing. This study aimed to evaluate the integrative effect of the oral SrR with a topical Chinese herbal paste, namely, CDR, on facilitation of bone healing. The efficacy was evaluated using rats with tibial fracture. They were treated with either CDR topically, or SrR orally, or their combined treatments. The results illustrated a significant additive effect of CDR on SrR in increasing the yield load of the fractured tibia. The results showed that neither SrR nor CDR exhibited a cytotoxic effect on UMR106 and bone-marrow stem cell (BMSC), but both of them increased the proliferation of BMSC at low concentrations. The combination of CDR at 200 g/mL with SrR at 200 or 400 g/ml also showed an additive effect on increasing the ALP activity of BMSC. Both SrR and CDR alone reduced osteoclast formation, and the effective concentration of SrR to inhibit osteoclastogenesis was reduced in the presence of CDR. This integrative approach by combining oral SrR and topical CDR is effective in promoting fracture healing properly due to their additive effects on proosteogenic and antiosteoclastogenic properties.

摘要

雷奈酸锶（SrR）是据报道对促进骨折愈合有效的药物之一。本研究旨在评估口服SrR与一种外用中药膏剂（即CDR）联合使用对促进骨愈合的综合效果。使用胫骨骨折大鼠评估疗效。它们分别接受局部CDR治疗、口服SrR治疗或联合治疗。结果表明，在增加骨折胫骨的屈服载荷方面，CDR对SrR具有显著的相加作用。结果显示，SrR和CDR对UMR106和骨髓干细胞（BMSC）均未表现出细胞毒性作用，但二者在低浓度时均能增加BMSC的增殖。200μg/mL的CDR与200或400μg/mL的SrR联合使用在增加BMSC的碱性磷酸酶（ALP）活性方面也表现出相加作用。单独使用SrR和CDR均可减少破骨细胞形成，且在存在CDR的情况下，抑制破骨细胞生成的SrR有效浓度降低。口服SrR与局部CDR联合使用的这种综合方法因其对促骨生成和抗破骨细胞生成特性的相加作用而有效地促进骨折正常愈合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/5804400/d13cfa66be16/ECAM2017-9795806.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/5804400/ac7c4673266d/ECAM2017-9795806.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/5804400/a8c246fdf496/ECAM2017-9795806.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/5804400/1b9d6b08581f/ECAM2017-9795806.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/5804400/6da56fad8f3e/ECAM2017-9795806.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/5804400/e8f768c42fd1/ECAM2017-9795806.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/5804400/d13cfa66be16/ECAM2017-9795806.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/5804400/ac7c4673266d/ECAM2017-9795806.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/5804400/a8c246fdf496/ECAM2017-9795806.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/5804400/1b9d6b08581f/ECAM2017-9795806.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/5804400/6da56fad8f3e/ECAM2017-9795806.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/5804400/e8f768c42fd1/ECAM2017-9795806.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a5c/5804400/d13cfa66be16/ECAM2017-9795806.006.jpg

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The effect of strontium ranelate on the healing of a fractured ulna with bone gap in rabbit.雷奈酸锶对兔尺骨骨缺损骨折愈合的影响。
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Strontium ranelate increases osteoblast activity.
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