[植物多糖对TH1依赖性免疫反应的影响：筛选研究]

[Effect of plant polysaccharides on TH1-dependent immune response: screening investigation].

作者信息

Danilets M G, Bel'skiĭ Iu P, Gur'ev A M, Belousov M V, Bel'skaia N V, Trofimova E S, Uchasova E G, Alhmedzhanov R R, Ligacheva A A, Iusbov M S, Agefonov V I

出版信息

Eksp Klin Farmakol. 2010 Jun;73(6):19-22.

PMID:20726346

Abstract

We have studied the influence of water-soluble polysaccharides isolated from Tussilago farfara L. leaves, Betula verrucosa Ehrh. leaves, Calendula officinalis L. flowers, Acorus calamus rhizomes, Inula helenium L. rhizomes, overground part of Trifolium pretense L., and overground part ofArtemisia absinthium L., on Thl immune response induced by sheep red blood cells and on NO production by murine peritoneal macrophages in vitro. All the investigated polysaccharides have stimulated a Th1 response. Polysaccharides isolated from Betula verrucosa leaves did not influence NO synthesis, while polysaccharides of Tussilago farfara leaves and Acorus calamus rhizomes stimulated NO synthase of murine macrophages on a level comparable with that of lipopolysaccharides (LPS). Polysaccharides from Inula helenium rhizomes, Calendula officinalis flowers, and overground parts of Trifolium pretense and Artemisia absinthium also stimulated NO production, but to a lower extent in comparison to LPS.

摘要

我们研究了从款冬叶、疣枝桦叶、金盏花花、菖蒲根茎、土木香根茎、红车轴草地上部分以及苦艾地上部分分离得到的水溶性多糖，对绵羊红细胞诱导的Th1免疫反应以及对体外培养的小鼠腹腔巨噬细胞产生一氧化氮（NO）的影响。所有研究的多糖均刺激了Th1反应。从疣枝桦叶中分离的多糖不影响NO的合成，而款冬叶和菖蒲根茎的多糖刺激小鼠巨噬细胞的NO合酶，其水平与脂多糖（LPS）相当。土木香根茎、金盏花花以及红车轴草和苦艾地上部分的多糖也刺激了NO的产生，但与LPS相比程度较低。