BCL2 家族蛋白在调控线粒体动态中的新作用。
New role of the BCL2 family of proteins in the regulation of mitochondrial dynamics.
机构信息
Dartmouth Medical School, Department of Genetics, Norris Cotton Cancer Center, 7400 Remsen, Hanover, NH 03755, USA.
出版信息
Curr Opin Cell Biol. 2010 Dec;22(6):852-8. doi: 10.1016/j.ceb.2010.07.014. Epub 2010 Aug 20.
Abstract
Mitochondria are highly dynamic organelles that constantly fuse and divide. Dynamin-related GTPases are the core components of the machineries that mediate mitochondrial fusion and fission. The role and regulation of these machineries are currently under intense investigation. Recently, members of the BCL2 family of proteins, conserved regulators of apoptosis, have been implicated in the regulation of mitochondrial dynamics. Here, we review the functions of mitochondrial fusion and fission in apoptotic and nonapoptotic cells and how members of the BCL2 family of proteins regulate these functions.
摘要
线粒体是高度动态的细胞器，不断融合和分裂。与 dynamin 相关的 GTP 酶是介导线粒体融合和裂变的机器的核心组成部分。这些机器的作用和调节目前正在深入研究中。最近，凋亡的保守调节因子 BCL2 家族蛋白成员被牵连到线粒体动力学的调节中。在这里，我们回顾了线粒体融合和裂变在凋亡和非凋亡细胞中的功能，以及 BCL2 家族蛋白成员如何调节这些功能。
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