脆弱拟杆菌荚膜多糖生物合成基因座启动子在共生和感染过程中的取向。
Orientations of the Bacteroides fragilis capsular polysaccharide biosynthesis locus promoters during symbiosis and infection.
机构信息
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
出版信息
J Bacteriol. 2010 Nov;192(21):5832-6. doi: 10.1128/JB.00555-10. Epub 2010 Aug 20.
Abstract
Orientations of the seven invertible polysaccharide biosynthesis locus promoters of Bacteroides fragilis were determined from bacteria grown in vitro, from feces of monoassociated and complex colonized mice, and from B. fragilis-induced murine abscesses. Bacteria grown in vivo have greater variability in orientation of polysaccharide locus promoters than culture-grown organisms.
摘要
脆弱拟杆菌 7 个可反转聚糖生物合成基因座启动子的取向，通过体外培养的细菌、单定植和复杂定植的小鼠粪便以及脆弱拟杆菌诱导的鼠脓肿进行了确定。与体外培养的生物体相比，体内生长的细菌在聚糖基因座启动子的取向方面具有更大的可变性。
相似文献
1
Orientations of the Bacteroides fragilis capsular polysaccharide biosynthesis locus promoters during symbiosis and infection.脆弱拟杆菌荚膜多糖生物合成基因座启动子在共生和感染过程中的取向。
J Bacteriol. 2010 Nov;192(21):5832-6. doi: 10.1128/JB.00555-10. Epub 2010 Aug 20.
2
Trans locus inhibitors limit concomitant polysaccharide synthesis in the human gut symbiont Bacteroides fragilis.转座子抑制剂限制了人类肠道共生菌脆弱拟杆菌的多糖同时合成。
Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11976-80. doi: 10.1073/pnas.1005039107. Epub 2010 Jun 14.
3
Promoter orientation of the immunomodulatory capsular polysaccharide A (PSA) is off in individuals with inflammatory bowel disease (IBD).免疫调节荚膜多糖 A（PSA）的启动子定向在炎症性肠病（IBD）患者中发生改变。
Gut Microbes. 2019;10(5):569-577. doi: 10.1080/19490976.2018.1560755. Epub 2019 Feb 7.
4
Analysis of a capsular polysaccharide biosynthesis locus of Bacteroides fragilis.脆弱拟杆菌荚膜多糖生物合成位点的分析
Infect Immun. 1999 Jul;67(7):3525-32. doi: 10.1128/IAI.67.7.3525-3532.1999.
5
Expression of a uniquely regulated extracellular polysaccharide confers a large-capsule phenotype to Bacteroides fragilis.一种独特调控的细胞外多糖的表达赋予脆弱拟杆菌大荚膜表型。
J Bacteriol. 2008 Feb;190(3):1020-6. doi: 10.1128/JB.01519-07. Epub 2007 Nov 26.
6
News & notes: adhesiveness of Bacteroides fragilis strains isolated from feces of healthy donors, abscesses, and blood.
Curr Microbiol. 1997 May;34(5):332-4. doi: 10.1007/s002849900191.
7
Multiple inverted DNA repeats of Bacteroides fragilis that control polysaccharide antigenic variation are similar to the hin region inverted repeats of Salmonella typhimurium.脆弱拟杆菌中控制多糖抗原变异的多个反向DNA重复序列与鼠伤寒沙门氏菌的hin区域反向重复序列相似。
Microbiology (Reading). 2003 Apr;149(Pt 4):915-924. doi: 10.1099/mic.0.26166-0.
8
A family of transcriptional antitermination factors necessary for synthesis of the capsular polysaccharides of Bacteroides fragilis.脆弱拟杆菌荚膜多糖合成所必需的转录抗终止因子家族。
J Bacteriol. 2009 Dec;191(23):7288-95. doi: 10.1128/JB.00500-09. Epub 2009 Oct 2.
9
Bacteroides fragilis NCTC9343 produces at least three distinct capsular polysaccharides: cloning, characterization, and reassignment of polysaccharide B and C biosynthesis loci.脆弱拟杆菌NCTC9343产生至少三种不同的荚膜多糖：多糖B和C生物合成位点的克隆、表征及重新分配。
Infect Immun. 2000 Nov;68(11):6176-81. doi: 10.1128/IAI.68.11.6176-6181.2000.
10
Infection with Bacteroides fragilis: pathogenesis and immunoprophylaxis in an animal model.脆弱拟杆菌感染：动物模型中的发病机制与免疫预防
Scand J Infect Dis Suppl. 1982;31:28-33.
引用本文的文献
1
Combinatorial phenotypic landscape enables bacterial resistance to phage infection.组合表型格局使细菌能够抵抗噬菌体感染。
bioRxiv. 2025 Jan 14:2025.01.13.632860. doi: 10.1101/2025.01.13.632860.
2
Bacteroides expand the functional versatility of a conserved transcription factor and transcribed DNA to program capsule diversity.拟杆菌扩展了保守转录因子和转录DNA的功能多样性，以规划荚膜多样性。
Nat Commun. 2024 Dec 30;15(1):10862. doi: 10.1038/s41467-024-55215-9.
3
Intragenic DNA inversions expand bacterial coding capacity.基因内 DNA 倒位可扩大细菌的编码能力。
Nature. 2024 Oct;634(8032):234-242. doi: 10.1038/s41586-024-07970-4. Epub 2024 Sep 25.
4
Single-cell analysis of multiple invertible promoters reveals differential inversion rates as a strong determinant of bacterial population heterogeneity.单细胞分析多个可反转启动子揭示了反转率的差异是细菌种群异质性的一个重要决定因素。
Sci Adv. 2023 Aug 4;9(31):eadg5476. doi: 10.1126/sciadv.adg5476.
5
Exploring the Gut-Brain Axis for the Control of CNS Inflammatory Demyelination: Immunomodulation by Polysaccharide A.探索肠道-脑轴控制中枢神经系统炎症性脱髓鞘：多糖 A 的免疫调节作用。
Front Immunol. 2021 May 5;12:662807. doi: 10.3389/fimmu.2021.662807. eCollection 2021.
6
Microbial adaptation to the healthy and inflamed gut environments.微生物对健康和炎症肠道环境的适应。
Gut Microbes. 2020 Nov 9;12(1):1857505. doi: 10.1080/19490976.2020.1857505.
7
Promoter orientation of the immunomodulatory capsular polysaccharide A (PSA) is off in individuals with inflammatory bowel disease (IBD).免疫调节荚膜多糖 A（PSA）的启动子定向在炎症性肠病（IBD）患者中发生改变。
Gut Microbes. 2019;10(5):569-577. doi: 10.1080/19490976.2018.1560755. Epub 2019 Feb 7.
8
Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in the gut.可反转启动子介导细菌的表型转换、抗生素耐药性和肠道中的宿主适应性。
Science. 2019 Jan 11;363(6423):181-187. doi: 10.1126/science.aau5238.
9
A Phase-Variable Surface Layer from the Gut Symbiont Bacteroides thetaiotaomicron.来自肠道共生菌多形拟杆菌的相变表面层。
mBio. 2015 Sep 29;6(5):e01339-15. doi: 10.1128/mBio.01339-15.
10
In vivo imaging and tracking of host-microbiota interactions via metabolic labeling of gut anaerobic bacteria.通过肠道厌氧细菌的代谢标记对宿主-微生物群相互作用进行体内成像和追踪。
Nat Med. 2015 Sep;21(9):1091-100. doi: 10.1038/nm.3929. Epub 2015 Aug 17.
本文引用的文献
1
Trans locus inhibitors limit concomitant polysaccharide synthesis in the human gut symbiont Bacteroides fragilis.转座子抑制剂限制了人类肠道共生菌脆弱拟杆菌的多糖同时合成。
Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11976-80. doi: 10.1073/pnas.1005039107. Epub 2010 Jun 14.
2
Role of glycan synthesis in colonization of the mammalian gut by the bacterial symbiont Bacteroides fragilis.聚糖合成在脆弱拟杆菌这一细菌共生体定殖于哺乳动物肠道中的作用。
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13099-104. doi: 10.1073/pnas.0804220105. Epub 2008 Aug 22.
3
A microbial symbiosis factor prevents intestinal inflammatory disease.一种微生物共生因子可预防肠道炎症性疾病。
Nature. 2008 May 29;453(7195):620-5. doi: 10.1038/nature07008.
4
Regulation of surface architecture by symbiotic bacteria mediates host colonization.共生细菌对表面结构的调控介导宿主定殖。
Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3951-6. doi: 10.1073/pnas.0709266105. Epub 2008 Mar 4.
5
Niche-specific features of the intestinal bacteroidales.肠道拟杆菌目的生态位特异性特征。
J Bacteriol. 2008 Jan;190(2):736-42. doi: 10.1128/JB.01559-07. Epub 2007 Nov 9.
6
Reemergence of anaerobic bacteremia.厌氧菌血症的再度出现。
Clin Infect Dis. 2007 Apr 1;44(7):895-900. doi: 10.1086/512197. Epub 2007 Feb 14.
7
Obesity alters gut microbial ecology.肥胖会改变肠道微生物生态。
Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11070-5. doi: 10.1073/pnas.0504978102. Epub 2005 Jul 20.
8
An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system.共生细菌的一种免疫调节分子指导宿主免疫系统的成熟。
Cell. 2005 Jul 15;122(1):107-18. doi: 10.1016/j.cell.2005.05.007.
9
Human symbionts use a host-like pathway for surface fucosylation.人类共生体利用一种类似宿主的途径进行表面岩藻糖基化。
Science. 2005 Mar 18;307(5716):1778-81. doi: 10.1126/science.1106469.
10
Estimating equations for association structures.关联结构的估计方程。
Stat Med. 2004 Mar 30;23(6):859-74; discussion 875-7,879-80. doi: 10.1002/sim.1650.
Zotero 插件