细胞黏附：整合细胞骨架动力学和细胞张力。
Cell adhesion: integrating cytoskeletal dynamics and cellular tension.
机构信息
Department of Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA.
出版信息
Nat Rev Mol Cell Biol. 2010 Sep;11(9):633-43. doi: 10.1038/nrm2957.
Abstract
Cell migration affects all morphogenetic processes and contributes to numerous diseases, including cancer and cardiovascular disease. For most cells in most environments, movement begins with protrusion of the cell membrane followed by the formation of new adhesions at the cell front that link the actin cytoskeleton to the substratum, generation of traction forces that move the cell forwards and disassembly of adhesions at the cell rear. Adhesion formation and disassembly drive the migration cycle by activating Rho GTPases, which in turn regulate actin polymerization and myosin II activity, and therefore adhesion dynamics.
摘要
细胞迁移影响所有形态发生过程，并导致许多疾病，包括癌症和心血管疾病。对于大多数细胞在大多数环境中，运动始于细胞膜的突起，随后在前部形成新的黏附，将肌动蛋白细胞骨架与基质连接起来，产生向前移动细胞的牵引力，并在后部解聚黏附。黏附的形成和解体通过激活 Rho GTPases 来驱动迁移周期，Rho GTPases 反过来又调节肌动蛋白聚合和肌球蛋白 II 活性，从而调节黏附动力学。
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本文引用的文献
1
The switchable integrin adhesome.可切换的整合素黏附体
J Cell Sci. 2010 May 1;123(Pt 9):1385-8. doi: 10.1242/jcs.066183.
2
Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation.肌球蛋白 II 活性通过 FAK 介导的黏着斑蛋白磷酸化调节衔接蛋白募集到黏附斑。
J Cell Biol. 2010 Mar 22;188(6):877-90. doi: 10.1083/jcb.200906012.
3
Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK).钙蛋白酶介导的粘着斑激酶（FAK）的蛋白水解作用对粘着动力学的调节。
J Biol Chem. 2010 Apr 9;285(15):11418-26. doi: 10.1074/jbc.M109.090746. Epub 2010 Feb 11.
4
Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1.张力蛋白2通过RhoGAP DLC1调节三维胶原凝胶中的细胞收缩性。
J Cell Biochem. 2010 Mar 1;109(4):808-17. doi: 10.1002/jcb.22460.
5
Unleashing formins to remodel the actin and microtubule cytoskeletons.释放formin 重塑肌动蛋白和微管细胞骨架。
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6
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7
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