Institut für Biochemie und Molekularbiologie, ZBMZ, Universität Freiburg, Stefan-Meier-Strabetae 17, 79104 Freiburg, Germany.
Nat Rev Mol Cell Biol. 2010 Sep;11(9):655-67. doi: 10.1038/nrm2959.
Mitochondria contain approximately 1,000 different proteins, most of which are imported from the cytosol. Two import pathways that direct proteins into the mitochondrial inner membrane and matrix have been known for many years. The identification of numerous new transport components in recent proteomic studies has led to novel mechanistic insight into these pathways and the discovery of new import pathways into the outer membrane and intermembrane space. Protein translocases do not function as independent units but are integrated into dynamic networks and are connected to machineries that function in bioenergetics, mitochondrial morphology and coupling to the endoplasmic reticulum.
线粒体含有大约 1000 种不同的蛋白质，其中大多数是从细胞质中输入的。多年来，人们已经知道有两种将蛋白质导入线粒体内膜和基质的输入途径。在最近的蛋白质组学研究中，发现了许多新的转运成分，这为这些途径提供了新的机制见解，并发现了进入外膜和膜间空间的新的输入途径。蛋白质转运酶不是作为独立的单元起作用，而是整合到动态网络中，并与参与生物能量学、线粒体形态和与内质网偶联的机制相连。
