Scorza F A, Cysneiros R M, Arida R M, Terra V C, Machado H R, Rabello G M M, Albuquerque M, Cavalheiro E A
Disciplina de Neurologia Experimental, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Botucatu, 862 Edifício Leal Prado, CEP 04023-900, São Paulo, Brazil.
Braz J Biol. 2010 Aug;70(3):665-70. doi: 10.1590/s1519-69842010000300026.
People with epilepsy have an increased risk of dying prematurely and the most common epilepsy-related category of death is sudden unexpected death in epilepsy (SUDEP). SUDEP is mainly a problem for patients with chronic uncontrolled epilepsy. The ultimate goal of research in SUDEP is to develop new methods to prevent it and actions other than medical and surgical therapies that could be very useful. Nutritional aspects, i.e., omega-3 fatty acids deficiency, could have an interesting role in this scenario. Some animal and clinical studies have suggested that omega-3 fatty acids could be useful in the prevention and treatment of epilepsy and hence SUDEP. It has been ascertained that the only foods that provide large amounts of omega-3 are seafood (fish and shellfish); however, some fish are contaminated with methylmercury, which may counteract the positive effects of omega-3 fatty acids. Our update review summarises the knowledge of the role of fish consumption on epilepsy research.
癫痫患者过早死亡的风险增加，与癫痫相关的最常见死亡类别是癫痫猝死（SUDEP）。SUDEP主要是慢性癫痫控制不佳患者面临的问题。SUDEP研究的最终目标是开发预防它的新方法以及除药物和手术治疗之外可能非常有用的措施。营养方面，即ω-3脂肪酸缺乏，在这种情况下可能发挥有趣的作用。一些动物和临床研究表明，ω-3脂肪酸可能有助于预防和治疗癫痫，从而预防SUDEP。已确定唯一能提供大量ω-3的食物是海鲜（鱼类和贝类）；然而，一些鱼类被甲基汞污染，这可能抵消ω-3脂肪酸的积极作用。我们的最新综述总结了鱼类消费在癫痫研究中作用的相关知识。
