Maturana Andrés D, Fujita Toshitsugu, Kuroda Shun'ichi
Department of Bioengineering, Nagaoka University of Technology, Niigata, Japan.
ScientificWorldJournal. 2010 Aug 17;10:1646-54. doi: 10.1100/tsw.2010.151.
Fasciculation and elongation protein zeta-1 (FEZ1) is a mammalian ortholog of the Caenorhabditis elegans UNC-76 protein that possesses four coiled-coil domains and a nuclear localization signal. It is mainly expressed in the brain. Suppression of FEZ1 expression in cultured embryonic neurons causes deficiency of neuronal differentiation. Recently, proteomic techniques revealed that FEZ1 interacts with various intracellular partners, such as signaling, motor, and structural proteins. FEZ1 was shown to act as an antiviral factor. The findings reported so far indicate that FEZ1 is associated with neuronal development, neuropathologies, and viral infection. Based on these accumulating evidences, we herein review the biological functions of FEZ1.
成束和延伸蛋白ζ-1（FEZ1）是秀丽隐杆线虫UNC-76蛋白的哺乳动物直系同源物，具有四个卷曲螺旋结构域和一个核定位信号。它主要在大脑中表达。在培养的胚胎神经元中抑制FEZ1的表达会导致神经元分化缺陷。最近，蛋白质组学技术揭示FEZ1与多种细胞内伴侣相互作用，如信号蛋白、运动蛋白和结构蛋白。FEZ1被证明是一种抗病毒因子。迄今为止报道的研究结果表明，FEZ1与神经元发育、神经病理学和病毒感染有关。基于这些越来越多的证据，我们在此综述FEZ1的生物学功能。
