Max Planck Institute of Psychiatry, Munich, Germany ; Department of Psychiatry and Psychotherapy, Regensburg University, Germany.
Curr Neuropharmacol. 2013 Mar;11(2):171-85. doi: 10.2174/1570159X11311020004.
Neuropsychiatric disorders are devastating mental illnesses with a high economic burden. The additional morbidity associated with social issues that arises along with the course of these diseases increases the need for a clear understanding of their etiopathogenesis to allow an implementation of novel pharmacological strategies. Yet a poor knowledge about interactions occurring at the glia-neuron interface in health and disease still hampers innovative discoveries, despite the fact that glia cells have been long described to actively participate in the regulation of brain circuits. The purpose of this review was to collect the scattered literature on the involvement of glia cells in neuropsychiatric disorders and to describe how also these cells besides neurons might be responsive to current pharmacological interventions. We hope thereby to offer alternative approaches for investigations that may open avenues to search for new potential targets for drug discovery.
神经精神疾病是具有高经济负担的破坏性精神疾病。随着这些疾病的发展而出现的与社会问题相关的额外发病率增加了对其病因发病机制的清晰理解的需求，以允许实施新的药理学策略。然而，尽管胶质细胞早已被描述为积极参与大脑回路的调节，但对健康和疾病中发生的相互作用的了解甚少，仍然阻碍了创新发现。本综述的目的是收集关于胶质细胞参与神经精神疾病的分散文献，并描述这些细胞除了神经元之外如何对当前的药理学干预做出反应。我们希望为此提供替代研究方法，这可能为寻找新的潜在药物靶点开辟途径。
