BIOAIR Lab, Department of General Thoracic and Regenerative Surgery and Intrathoracic Biotransplantation, University Hospital Careggi, Largo Brambilla 3, 50134, Florence, Italy.
Cell Mol Life Sci. 2010 Dec;67(24):4185-96. doi: 10.1007/s00018-010-0499-z. Epub 2010 Aug 21.
There are a variety of airway diseases with different clinical settings, which may extend from a surgical approach to total organ replacement. Tissue engineering involves modifying cells or tissues in order to repair, regenerate, or replace tissue in the body and seems to be a promising approach for airway replacement. The successful implantation of stem-cell-based tissue-engineered trachea in a young woman with end-stage post-tuberculosis left main bronchus collapse serves as a prototype for the airway tissue-engineered-based approach. The trachea indeed could represent a perfect model system to investigate the translational aspects of tissue engineering, largely due to its low-oxygen needs. This review highlights the anatomy of the airways, the various disease conditions that cause damage to the airways, elaborates on the essential components of the tissue-engineering approach, and discusses the success of the revolutionary trachea transplantation approach.
有多种气道疾病具有不同的临床特征，可能需要从手术方法扩展到整个器官置换。组织工程学涉及对细胞或组织进行修饰，以修复、再生或替代体内组织，这似乎是气道置换的一种很有前途的方法。一名年轻的患有终末期肺结核左主支气管塌陷的女性成功植入基于干细胞的组织工程气管，为气道组织工程方法提供了一个范例。气管确实可以作为一个理想的模型系统来研究组织工程的转化方面，这在很大程度上是由于其低氧需求。这篇综述强调了气道的解剖结构、导致气道损伤的各种疾病状况，详细阐述了组织工程方法的基本组成部分，并讨论了革命性的气管移植方法的成功。
