免疫细胞在产后乳腺发育过程中的位置和功能。
Immune cell location and function during post-natal mammary gland development.
机构信息
Department of Lab Medicine and Pathology, Graduate Program in Microbiology, Immunology and Cancer Biology, Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
出版信息
J Mammary Gland Biol Neoplasia. 2010 Sep;15(3):329-39. doi: 10.1007/s10911-010-9188-7. Epub 2010 Aug 24.
Abstract
Post-natal mammary gland development requires complex interactions between the epithelial cells and various cell types within the stroma. Recent studies have illustrated the importance of immune cells and their mediators during the various stages of mammary gland development. However, the mechanisms by which these immune cells functionally contribute to mammary gland development are only beginning to be understood. This review provides an overview of the localization of immune cells within the mammary gland during the various stages of post-natal mammary gland development. Furthermore, recent studies are summarized that illustrate the mechanisms by which these cells are recruited to the mammary gland and their functional roles in mammary gland development.
摘要
产后乳腺发育需要上皮细胞和基质中各种细胞类型之间的复杂相互作用。最近的研究表明，免疫细胞及其介质在乳腺发育的各个阶段都很重要。然而，这些免疫细胞如何在功能上有助于乳腺发育的机制才刚刚开始被理解。这篇综述概述了免疫细胞在产后乳腺发育的各个阶段在乳腺中的定位。此外，还总结了最近的研究，说明了这些细胞被招募到乳腺中的机制及其在乳腺发育中的功能作用。
相似文献
1
Immune cell location and function during post-natal mammary gland development.免疫细胞在产后乳腺发育过程中的位置和功能。
J Mammary Gland Biol Neoplasia. 2010 Sep;15(3):329-39. doi: 10.1007/s10911-010-9188-7. Epub 2010 Aug 24.
2
Cytokine signalling in mammary gland development.细胞因子信号在乳腺发育中的作用。
J Reprod Immunol. 2011 Mar;88(2):124-9. doi: 10.1016/j.jri.2010.11.006. Epub 2011 Jan 20.
3
Immune Cell Contribution to Mammary Gland Development.免疫细胞对乳腺发育的贡献。
J Mammary Gland Biol Neoplasia. 2024 Aug 23;29(1):16. doi: 10.1007/s10911-024-09568-y.
4
Fibroblasts: The grey eminence of mammary gland development.成纤维细胞：乳腺发育中的灰色小体。
Semin Cell Dev Biol. 2021 Jun;114:134-142. doi: 10.1016/j.semcdb.2020.10.012. Epub 2020 Nov 4.
5
[Progress on the miRNA related with mammary gland development and lactation].[与乳腺发育和泌乳相关的微小RNA研究进展]
Yi Chuan. 2013 Jun;35(6):695-702. doi: 10.3724/sp.j.1005.2013.00695.
6
Leukocytes in mammary development and cancer.乳腺发育和癌症中的白细胞。
Cold Spring Harb Perspect Biol. 2011 Mar 1;3(3):a003285. doi: 10.1101/cshperspect.a003285.
7
Hormonal regulation of the immune microenvironment in the mammary gland.乳腺中免疫微环境的激素调节
J Mammary Gland Biol Neoplasia. 2014 Jul;19(2):229-39. doi: 10.1007/s10911-014-9324-x. Epub 2014 Jul 4.
8
Mammary stroma in development and carcinogenesis.乳腺基质在发育和癌变中的作用。
J Mammary Gland Biol Neoplasia. 2013 Jun;18(2):189-97. doi: 10.1007/s10911-013-9281-9. Epub 2013 Apr 21.
9
The molecular basis of mammary gland development and epithelial differentiation.乳腺发育和上皮分化的分子基础。
Semin Cell Dev Biol. 2021 Jun;114:93-112. doi: 10.1016/j.semcdb.2020.09.014. Epub 2020 Oct 17.
10
Estrogen receptor-α signaling in post-natal mammary development and breast cancers.雌激素受体-α在产后乳腺发育和乳腺癌中的信号转导。
Cell Mol Life Sci. 2021 Aug;78(15):5681-5705. doi: 10.1007/s00018-021-03860-4. Epub 2021 Jun 22.
引用本文的文献
1
Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis.乳腺上皮内淋巴细胞和肠道输入影响泌乳过程中的T细胞动态变化。
Nat Immunol. 2025 Aug;26(8):1411-1422. doi: 10.1038/s41590-025-02218-3. Epub 2025 Jul 29.
2
Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness.乳腺上皮内淋巴细胞促进泌乳及后代健康。
Cell. 2025 Mar 20;188(6):1662-1680.e24. doi: 10.1016/j.cell.2025.01.028. Epub 2025 Feb 14.
3
Loss of STING impairs lactogenic differentiation.STING 缺失会损害泌乳分化。
Development. 2024 Oct 1;151(19). doi: 10.1242/dev.202998. Epub 2024 Oct 14.
4
Immune Cell Contribution to Mammary Gland Development.免疫细胞对乳腺发育的贡献。
J Mammary Gland Biol Neoplasia. 2024 Aug 23;29(1):16. doi: 10.1007/s10911-024-09568-y.
5
C/EBPβ deletion in macrophages impairs mammary gland alveolar budding during the estrous cycle.C/EBPβ 缺失导致巨噬细胞在动情周期中乳腺腺泡芽生受损。
Life Sci Alliance. 2024 Jul 18;7(10). doi: 10.26508/lsa.202302516. Print 2024 Oct.
6
Defining and targeting macrophage heterogeneity in the mammary gland and breast cancer.定义和靶向乳腺和乳腺癌中的巨噬细胞异质性。
Cancer Med. 2024 Feb;13(3):e7053. doi: 10.1002/cam4.7053.
7
Epigenetic modulation of antitumor immunity and immunotherapy response in breast cancer: biological mechanisms and clinical implications.乳腺癌中抗肿瘤免疫和免疫治疗反应的表观遗传调控：生物学机制和临床意义。
Front Immunol. 2024 Jan 10;14:1325615. doi: 10.3389/fimmu.2023.1325615. eCollection 2023.
8
Collagen induction of immune cells in the mammary glands during pregnancy.怀孕期间乳腺中免疫细胞的胶原诱导。
Physiol Genomics. 2024 Feb 1;56(2):128-135. doi: 10.1152/physiolgenomics.00098.2023. Epub 2023 Nov 13.
9
Recent Advances in the Aging Microenvironment of Breast Cancer.乳腺癌衰老微环境的最新进展
Cancers (Basel). 2022 Oct 12;14(20):4990. doi: 10.3390/cancers14204990.
10
The immune environment of the mammary gland fluctuates during post-lactational regression and correlates with tumour growth rate.乳腺的免疫环境在哺乳期后退化过程中波动，并与肿瘤生长速度相关。
Development. 2022 Apr 15;149(8). doi: 10.1242/dev.200162. Epub 2022 Apr 29.
本文引用的文献
1
Mast cell-orchestrated immunity to pathogens.肥大细胞协调的病原体免疫。
Nat Rev Immunol. 2010 Jun;10(6):440-52. doi: 10.1038/nri2782.
2
IgE, mast cells, basophils, and eosinophils.免疫球蛋白 E、肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞。
J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S73-80. doi: 10.1016/j.jaci.2009.11.017.
3
IgA ASC accumulation to the lactating mammary gland is dependent on VCAM-1 and alpha4 integrins.IgA ASC 在哺乳期乳腺中的积累依赖于 VCAM-1 和 alpha4 整合素。
Mol Immunol. 2010 Apr;47(7-8):1608-12. doi: 10.1016/j.molimm.2010.01.015. Epub 2010 Feb 19.
4
Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species.在不同物种中，活化的巨噬细胞和胶原重塑是产后退化的乳腺的特征。
Am J Pathol. 2010 Mar;176(3):1241-55. doi: 10.2353/ajpath.2010.090735. Epub 2010 Jan 28.
5
Role of macrophages in normal wound healing: an overview.巨噬细胞在正常伤口愈合中的作用：概述
J Wound Care. 2009 Aug;18(8):349-51. doi: 10.12968/jowc.2009.18.8.43636.
6
Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis.肥大细胞在乳腺分支形态发生过程中对基质微环境有贡献。
Dev Biol. 2010 Jan 1;337(1):124-33. doi: 10.1016/j.ydbio.2009.10.021. Epub 2009 Oct 20.
7
IL-5- and eosinophil-mediated inflammation: from discovery to therapy.白细胞介素 5-和嗜酸性粒细胞介导的炎症：从发现到治疗。
Int Immunol. 2009 Dec;21(12):1303-9. doi: 10.1093/intimm/dxp102. Epub 2009 Oct 9.
8
Resident macrophages influence stem cell activity in the mammary gland.驻留巨噬细胞影响乳腺中的干细胞活性。
Breast Cancer Res. 2009;11(4):R62. doi: 10.1186/bcr2353. Epub 2009 Aug 26.
9
The physiology of wound healing: injury through maturation.伤口愈合的生理学：从损伤到成熟。
Surg Clin North Am. 2009 Jun;89(3):599-610. doi: 10.1016/j.suc.2009.03.006.
10
Macrophages in breast cancer: do involution macrophages account for the poor prognosis of pregnancy-associated breast cancer?乳腺癌中的巨噬细胞： involution巨噬细胞是否是妊娠相关乳腺癌预后不良的原因？
J Mammary Gland Biol Neoplasia. 2009 Jun;14(2):145-57. doi: 10.1007/s10911-009-9118-8. Epub 2009 Apr 8.
Zotero 插件