Jiang Xiaocong, Shen Haixing, Shang Xi, Fang Jianwen, Lu Yuexin, Lu Yue, Zheng Jingyan, Fu Peifen
Department of Breast Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
School of Medicine, Zhejiang University, Hangzhou 310003, China.
Cancers (Basel). 2022 Oct 12;14(20):4990. doi: 10.3390/cancers14204990.
Aging is one of the risk factors for advanced breast cancer. With the increasing trend toward population aging, it is important to study the effects of aging on breast cancer in depth. Cellular senescence and changes in the aging microenvironment in vivo are the basis for body aging and death. In this review, we focus on the influence of the aging microenvironment on breast cancer. Increased breast extracellular matrix stiffness in the aging breast extracellular matrix can promote the invasion of breast cancer cells. The role of senescence-associated secretory phenotypes (SASPs) such as interleukin-6 (IL-6), IL-8, and matrix metalloproteases (MMPs), in breast cancer cell proliferation, invasion, and metastasis is worthy of exploration. Furthermore, the impact of senescent fibroblasts, adipocytes, and endothelial cells on the mammary matrix is discussed in detail. We also list potential targets for senotherapeutics and senescence-inducing agents in the aging microenvironment of breast cancer. In conclusion, this review offers an overview of the influence of the aging microenvironment on breast cancer initiation and progression, with the aim of providing some directions for future research on the aging microenvironment in breast cancer.
衰老为晚期乳腺癌的风险因素之一。随着人口老龄化趋势加剧，深入研究衰老对乳腺癌的影响具有重要意义。细胞衰老及体内衰老微环境的变化是机体衰老与死亡的基础。在本综述中，我们聚焦于衰老微环境对乳腺癌的影响。衰老的乳腺细胞外基质中乳腺细胞外基质硬度增加可促进乳腺癌细胞的侵袭。衰老相关分泌表型（SASP）如白细胞介素-6（IL-6）、IL-8和基质金属蛋白酶（MMP）在乳腺癌细胞增殖、侵袭及转移中的作用值得探究。此外，还详细讨论了衰老的成纤维细胞、脂肪细胞和内皮细胞对乳腺基质的影响。我们还列出了乳腺癌衰老微环境中衰老治疗药物和衰老诱导剂的潜在靶点。总之，本综述概述了衰老微环境对乳腺癌发生发展的影响，旨在为未来乳腺癌衰老微环境的研究提供一些方向。
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