Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1881, USA.
J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S73-80. doi: 10.1016/j.jaci.2009.11.017.
IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to FcepsilonRI receptors on mast cells and basophils, is central to the initiation and propagation of immediate hypersensitivity reactions. Mast cells, basophils, and eosinophils are central effector cells in allergic inflammation, as well as in innate and adaptive immunity. This review highlights what is known about these components and their roles in disease pathogenesis.
IgE、肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞是过敏炎症的重要组成部分。抗原特异性 IgE 的产生，随后 IgE 与肥大细胞和嗜碱性粒细胞上的 FcepsilonRI 受体结合，是速发型超敏反应启动和传播的核心。肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞是过敏炎症以及先天和适应性免疫的中心效应细胞。本文重点介绍了这些成分及其在疾病发病机制中的作用。
