Liu Yao, Qin Huadong, Zhang Yi, Shi Tiefeng, Liu Bing, Sun Yu, Ma Yanfei
The Fourth Department of General Surgery, Harbin Medical University, Heilongjiang Province, China.
Hepatogastroenterology. 2011 Nov-Dec;58(112):1926-9. doi: 10.5754/hge10215.
BACKGROUND/AIMS: Studies investigating the association between p53 codon 72 polymorphism and colorectal cancer risk report conflicting results. In order to clarify this, we carried out a meta-analysis using published data to obtain more precise estimates of risk.
Electronic searches of PubMed and EMBASE were conducted to select studies for this meta- analysis. The principal outcome measure was the odds ratio (OR) with 95% confidence interval (CI) for the risk of colorectal cancer associated with p53 codon 72 genotype.
We identified seven epidemiological studies, which included 1964 colorectal cancer cases and 2943 controls. The combined results based on all studies showed that there was no significant difference in genotype distribution [Arg/Arg (OR=0.86, 95% CI=0.68, 1.08); Pro/Pro (OR=1.27, 95% CI=0.96, 1.68); Pro/Arg (OR=1.04, 95% CI=0.92, 1.17)] between colorectal cancer and non-cancer patients. When stratifying for race, we found that patients with colorectal cancer had a significantly higher frequency of Pro/ Pro (OR=1.79, 95% CI=1.37, 2.35) and lower frequency of Arg/Arg (OR=0.66, 95% CI=0.44, 0.98) than controls among Asians. No statistical association was found between this genotype and alcohol, tobacco, stage, histological differentiation, lymph node metastasis of colorectal cancer.
Our meta-analysis suggests that the p53 codon 72 polymorphism may be associated with colorectal cancer among Asians.
背景/目的：关于p53密码子72多态性与结直肠癌风险之间关联的研究结果相互矛盾。为了阐明这一点，我们利用已发表的数据进行了一项荟萃分析，以获得更精确的风险估计值。
通过电子检索PubMed和EMBASE来选择用于该荟萃分析的研究。主要结局指标是与p53密码子72基因型相关的结直肠癌风险的比值比（OR）及其95%置信区间（CI）。
我们确定了7项流行病学研究，其中包括1964例结直肠癌病例和2943例对照。基于所有研究的综合结果显示，结直肠癌患者与非癌症患者之间的基因型分布[Arg/Arg（OR = 0.86，95% CI = 0.68，1.08）；Pro/Pro（OR = 1.27，95% CI = 0.96，1.68）；Pro/Arg（OR = 1.04，95% CI = 0.92，1.17）]没有显著差异。按种族分层时，我们发现亚洲人中结直肠癌患者的Pro/Pro频率显著高于对照组（OR = 1.79，95% CI = 1.37，2.35），而Arg/Arg频率低于对照组（OR = 0.66，95% CI = 0.
