World J Gastroenterol. 2010 Aug 28;16(32):3995-4002. doi: 10.3748/wjg.v16.i32.3995.
Acute pancreatitis (AP) is an inflammatory condition of the pancreas caused by an imbalance in factors involved in maintaining cellular homeostasis. Earliest events in AP occur within acinar cells accompanied by other principal contributors to the inflammatory response i.e. the endothelial cells, immunocytes (granulocytes, monocytes/macrophages, lymphocytes) and neutrophils. Monocytes/macrophages are important inflammatory mediators, involved in the pathophysiology of AP, known to reside in the peritoneal cavity (in the vicinity of the pancreas) and in peripancreatic tissue. Recent studies suggested that impaired clearance of injured acini by macrophages is associated with an altered cytokine reaction which may constitute a basis for progression of AP. This review focuses on the role of monocytes/macrophages in progression of AP and discusses findings on the inflammatory process involved.
急性胰腺炎（AP）是一种胰腺炎症性疾病，由维持细胞内稳态的因素失衡引起。AP 的最早事件发生在胰腺泡细胞内，同时伴有其他主要炎症反应的贡献者，即内皮细胞、免疫细胞（粒细胞、单核细胞/巨噬细胞、淋巴细胞）和中性粒细胞。单核细胞/巨噬细胞是重要的炎症介质，参与 AP 的病理生理学，已知存在于腹腔（胰腺附近）和胰周组织中。最近的研究表明，巨噬细胞清除受损胰腺泡的能力受损与细胞因子反应的改变有关，这可能是 AP 进展的基础。这篇综述重点讨论了单核细胞/巨噬细胞在 AP 进展中的作用，并讨论了涉及的炎症过程的发现。
