Gerding D N, Hitt J A
Department of Medicine, Veterans Administration Medical Center, Minneapolis, Minnesota 55417.
Rev Infect Dis. 1989 Jul-Aug;11 Suppl 5:S1046-57. doi: 10.1093/clinids/11.supplement_5.s1046.
Data on the penetration of new quinolones into selected extravascular sites in humans, i.e., blister fluid, sputum, prostatic secretions, cerebrospinal fluid, aqueous humor, bone, prostate tissue, and cells, are reviewed and the data presented in tabular form. Published reports indicate that penetration into all sites, including intracellular sites, is high and exceeds that achievable for other commonly used antimicrobial agents, including penicillins, cephalosporins, and aminoglycosides. Available clinical treatment data support the expected favorable outcome predicted by the high extravascular concentrations achieved with quinolones.
回顾了关于新型喹诺酮类药物在人体选定血管外部位（即水疱液、痰液、前列腺分泌物、脑脊液、房水、骨骼、前列腺组织和细胞）中的渗透数据，并以表格形式呈现这些数据。已发表的报告表明，喹诺酮类药物在所有部位（包括细胞内部位）的渗透率都很高，超过了其他常用抗菌药物（包括青霉素、头孢菌素和氨基糖苷类）所能达到的渗透率。现有的临床治疗数据支持了喹诺酮类药物在血管外达到高浓度所预测的良好预期结果。
