百日咳博德特氏菌和副百日咳博德特氏菌对六种新型口服头孢菌素的体外敏感性
In vitro susceptibilities of Bordetella pertussis and Bordetella parapertussis to six new oral cephalosporins.
作者信息
Hoppe J E, Müller J
机构信息
University Children's Hospital, Tübingen, Federal Republic of Germany.
出版信息
Antimicrob Agents Chemother. 1990 Jul;34(7):1442-3. doi: 10.1128/AAC.34.7.1442.
Abstract
Of six new oral cephalosporins, cefixime and cefpodoxime were the most active (MIC for 90% of isolates tested [MIC90], 16 micrograms/ml) against Bordetella pertussis, followed by cefetamet, cefprozil, and loracarbef (LY163892) (MIC90, 64 micrograms/ml) and ceftibuten (MIC90, 128 micrograms/ml). Against Bordetella parapertussis, loracarbef was more active (MIC90, 32 micrograms/ml) than the other compounds tested (MIC90s, 64 to greater than 128 micrograms/ml). The new oral cephalosporins are unlikely to play a role in pertussis treatment.
摘要
在六种新型口服头孢菌素中，头孢克肟和头孢泊肟对百日咳博德特氏菌的活性最强（对90%受试分离株的最低抑菌浓度[MIC90]为16微克/毫升），其次是头孢他美、头孢丙烯和氯碳头孢（LY163892）（MIC90为64微克/毫升）以及头孢布烯（MIC90为128微克/毫升）。对于副百日咳博德特氏菌，氯碳头孢比其他受试化合物（MIC90为64至大于128微克/毫升）的活性更强（MIC90为32微克/毫升）。新型口服头孢菌素不太可能在百日咳治疗中发挥作用。
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