Macura Anna B, Witalis Jadwiga
Zakład Mykologii Katedry Mikrobiologii Collegium Medicum UJ w Krakowie.
Przegl Epidemiol. 2010;64(2):313-7.
The mycological examination of 2242 stool specimens sampled form patients with non-specific gastrointestinal tract ailments was focused on the spectrum of fungal species isolated in culture, the frequency of isolation of the particular species high enough to indicate microbiological imbalance in the gut flora as well as evaluation of the fungal susceptibility to the antifungal agents. Fungal presence was detected in 61.5% of the specimens tested. The fungal flora isolated was as follows: C. albicans 70.9% of the isolates, Candida non-albicans 20.8% (including C krusei 3.40%, C. parapsilosis 1.88%, C. glabrata 1.59%), other genera 8.34% (including S. cerevisiae 5.58%, Geotrichum sp. 1.16%, and Trichosporon sp. 1.01%). The results of semiquantitative evaluation of the intensity of growth of the fungi isolated from the stool revealed that imbalance in the gut flora occured in 20.8% of the cases. Candida strains tested using Fungitest were less susceptible to azoles than to amphotericin B and 5-fluorocytosine. Decreased susceptibiliy or resistance to antimycotics was relatively often found among Candida non-albicans strains.
对2242份取自患有非特异性胃肠道疾病患者的粪便标本进行真菌学检查，重点关注培养物中分离出的真菌种类谱、特定种类的分离频率（高到足以表明肠道菌群存在微生物失衡）以及真菌对抗真菌药物的敏感性评估。在所检测的标本中，61.5%检测到真菌存在。分离出的真菌菌群如下：白色念珠菌占分离株的70.9%，非白色念珠菌占20.8%（包括克鲁斯念珠菌3.40%、近平滑念珠菌1.88%、光滑念珠菌1.59%），其他属占8.34%（包括酿酒酵母5.58%、地霉属1.16%、丝孢酵母属1.01%）。对从粪便中分离出的真菌生长强度进行半定量评估的结果显示，20.8%的病例出现肠道菌群失衡。使用真菌检测法检测的念珠菌菌株对唑类药物的敏感性低于两性霉素B和5-氟胞嘧啶。在非白色念珠菌菌株中，相对经常发现对抗真菌药物的敏感性降低或耐药。
