Department of Community Health Sciences, College of Applied Medical Science, Riyadh, Kingdom of Saudi Arabia.
Endocr J. 2010;57(10):915-23. doi: 10.1507/endocrj.k10e-145. Epub 2010 Aug 21.
Understanding the interplay between sleep duration and quality, diet and hormones of obesity may help design effective lifestyle intervention strategies. Here we studied such associations in lean and obese teen-aged Saudi girls. In this cross-sectional observational study, 126 girls (62 lean and 64 obese) aged 14 -18 years (16.5 ± 1.5) were evaluated. A general questionnaire, which included sleep and diet questions, was obtained and anthropometric measurements and overnight fasting blood samples for determination of glucose, lipid profile and serum levels of leptin, adiponectin, resistin and ghrelin were collected. Subjects that slept < 5 hours/day had a higher percent of carbohydrate intake (p = 0.04) than those who slept > 7 hours/day. Adiponectin levels were higher in the lean than the obese group and increased in proportion to hours of sleep. Ghrelin had an inverse association with subjective sleep duration (p = 0.04), while resistin levels were directly proportional to it. Thus, the duration and quality of sleep influenced diet composition and the circulating levels of adipocytokines and ghrelin in adolescent girls. Long and uninterrupted sleep was associated with a better diet and a more favorable hormonal profile.
了解睡眠时长和质量、饮食和肥胖症激素之间的相互作用，可能有助于设计有效的生活方式干预策略。在这里，我们研究了沙特青少年瘦型和肥胖型女孩中这些关联。在这项横断面观察性研究中，评估了 126 名年龄在 14-18 岁（16.5±1.5）的女孩（62 名瘦型和 64 名肥胖型）。获得了一份一般问卷，其中包括睡眠和饮食问题，同时收集了人体测量学测量值和过夜禁食血样，以测定血糖、血脂谱以及血清瘦素、脂联素、抵抗素和胃饥饿素水平。与睡眠时间>7 小时/天的人相比，每天睡眠时间<5 小时的人碳水化合物摄入量的百分比更高（p=0.04）。瘦素组的脂联素水平高于肥胖组，并且与睡眠时间成正比增加。胃饥饿素与主观睡眠时间呈负相关（p=0.04），而抵抗素水平与之成正比。因此，睡眠的时长和质量影响了青少年女孩的饮食成分以及循环脂联素和胃饥饿素水平。长时间且不间断的睡眠与更好的饮食和更有利的激素谱相关。
