[房水中的过氧化氢与人类糖尿病性白内障的形成]

[Hydrogen peroxide in the aqueous humor and cataract formation in human diabetes].

作者信息

Simonelli F, Pensa M, Teramo P, Amicone A, Russo P, Perillo F, Cotticelli L, Rinaldi E

机构信息

Clinica Oculistica della I Facoltà di Medicina e Chirurgia Università di Napoli.

出版信息

Boll Soc Ital Biol Sper. 1990 Sep;66(9):879-85.

PMID:2073389

Abstract

Hydrogen peroxide in the aqueous humor was measured in cataractous eyes from normal subjects and in cataractous eyes from diabetic subjects. The level of H2O2 in the aqueous humor was significantly higher in diabetes than in the idiopathic forms. It is likely that in the eye, impaired enzymic defenses lead to the accumulation of reactive species of O2, such as H2O2, which induces lipid peroxidation. This mechanism may be involved, as a direct consequence of retinal damage, in the pathogenesis of cataract in diabetes.

摘要

对正常受试者的白内障眼以及糖尿病受试者的白内障眼房水中的过氧化氢进行了测量。糖尿病患者房水中的H2O2水平显著高于特发性白内障患者。在眼睛中，酶防御功能受损可能导致O2的活性物质如H2O2积累，进而引发脂质过氧化。作为视网膜损伤的直接后果，这种机制可能参与了糖尿病性白内障的发病过程。