Department of Organic Chemistry, University of Geneva, Quai Ernest Ansermet 30, CH-1211 Geneva, Switzerland.
Chem Commun (Camb). 2010 Oct 21;46(39):7295-306. doi: 10.1039/c0cc02309d. Epub 2010 Aug 24.
All-carbon quaternary stereocenters are ubiquitous motifs in biological products and pharmaceutical agents. However, due to sterical reasons, these centers are not always easily accessible. The metal-catalyzed conjugate addition reaction to trisubstituted conjugated substrates presents a viable methodology to create quaternary centers. In this article, different ways of activating the conjugate system towards nucleophilic addition will be described. An overview will be given on the different types of quaternary centers that are accessible through the conjugate addition reaction.
全碳季碳立体中心在生物制品和药物制剂中无处不在。然而，由于空间位阻的原因，这些中心并不总是容易接近的。金属催化的三取代共轭底物的共轭加成反应为构建季碳中心提供了一种可行的方法。本文将描述几种激活共轭体系以进行亲核加成的方法。综述了通过共轭加成反应可获得的不同类型的季碳中心。
