Sutherland A D, Jones G E, Poxton I R
Moredun Research Institute, Edinburgh, U.K.
FEMS Microbiol Immunol. 1990 Dec;2(5-6):269-78. doi: 10.1111/j.1574-6968.1990.tb03529.x.
Pasteurella haemolytica organisms grown in vivo were examined for their susceptibility to ovine immune mechanisms in vitro. Compared with in vitro grown organisms they were less susceptible to opsonophagocytosis and, in contrast, susceptible to complement-dependent killing in the absence of exogenous antibody. These differences were not associated with phenotypic changes in the surface of the bacterial cell. However, overproduction and de novo synthesis of proteins was observed in in vivo grown organisms. Also, bound host-immunoglobulin was observed on in vivo grown organisms and a role for this in modifying the interaction with immune mechanisms is discussed.
对体内生长的溶血巴斯德氏菌进行体外检测，以观察其对绵羊免疫机制的敏感性。与体外生长的细菌相比，它们对调理吞噬作用的敏感性较低，相反，在没有外源性抗体的情况下，它们对补体依赖性杀伤敏感。这些差异与细菌细胞表面的表型变化无关。然而，在体内生长的细菌中观察到蛋白质的过量产生和从头合成。此外，在体内生长的细菌上观察到结合的宿主免疫球蛋白，并讨论了其在改变与免疫机制相互作用中的作用。
