Agadzhanian A V, Suskov I I
Genetika. 2010 Jun;46(6):834-43.
Analysis of peripheral blood lymphocytes in children born after the accident at the Chernobyl Nuclear Power Plant in the period from 1987 to 2004 (permanent residents of territories contaminated with radionuclides, n = 92; and children of irradiated fathers-liquidators, n = 88)) revealed increased levels of aberrant cells (ACs) and aberrations of the chromosomal type as compared to the control (P < 0.05). In three subgroups of children with different initial AC frequencies (children with high AC frequencies, > or = 3%; children with medium AC frequencies, 2%; and children with low AC frequencies, > or = 1%), the levels of aberrations of the chromosomal type are increased as compared to the control (P < 0.05). The levels of aberrant cells and chromosome aberrations (CAs) in the subgroup of children with > or = 3% frequencies significantly differ from those in the subgroup of children with > or = 1% AC frequencies. No dependence of the AC and CA frequencies on the year of birth after the Chernobyl accident was revealed. After fractional and single gamma-irradiation (137Cs) of blood in vitro in the 10-30 cGy dose range, the average CA frequencies in the first and second mitoses increased in a similar way depending on the initial AC frequencies in the children and parents. All these results suggest an individual character ofgenomic instability induced by low radiation doses and its transgenerational phenomenon in the organisms of children.
对1987年至2004年期间切尔诺贝利核电站事故后出生的儿童（受放射性核素污染地区的永久居民，n = 92；以及受辐射父亲（清理人员）的子女，n = 88）外周血淋巴细胞的分析显示，与对照组相比，异常细胞（ACs）水平和染色体类型畸变增加（P < 0.05）。在初始AC频率不同的三个儿童亚组中（AC频率高的儿童，≥3%；AC频率中等的儿童，2%；AC频率低的儿童，≥1%），与对照组相比，染色体类型畸变水平增加（P < 0.05）。AC频率≥3%的儿童亚组中的异常细胞水平和染色体畸变（CAs）与AC频率≥1%的儿童亚组中的显著不同。未发现AC和CA频率与切尔诺贝利事故后的出生年份有相关性。在体外对血液进行10 - 30 cGy剂量范围的分次和单次γ射线（137Cs）照射后，第一次和第二次有丝分裂中的平均CA频率根据儿童和父母的初始AC频率以类似方式增加。所有这些结果表明低辐射剂量诱导的基因组不稳定性具有个体特征及其在儿童机体中的跨代现象。
