无外消旋化的 N-叔丁基亚磺酰基酮亚胺的合成方法。
Racemization free protocol for the synthesis of N-tert-butanesulfinyl ketimines.
机构信息
Department of Chemistry, University of California, Berkeley, California 94720, USA.
出版信息
J Org Chem. 2010 Sep 17;75(18):6283-5. doi: 10.1021/jo1011625.
PMID:20735147
Abstract
A general and robust racemization-free protocol for the synthesis of a variety of N-tert-butanesulfinyl ketimines is reported. Reaction progress was monitored by (1)H NMR using the nonperturbing internal standard diglyme, and ketimines were formed in good to high yields in either THF or CPME (cyclopentyl methyl ether) as solvent with heating to reflux.
摘要
现报道一种通用且稳健的外消旋无的 N-叔丁基亚磺酰基酮亚胺的合成方法。通过使用无干扰内标二甘醇的 (1)H NMR 监测反应进程，在 THF 或 CPME（环戊基甲基醚）溶剂中加热回流时，酮亚胺以良好至高产率形成。
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