叔丁基亚磺亚胺的立体选择性氮杂-Darzens 反应：手性氮杂环丙烷的方便合成。
Stereoselective aza-Darzens reactions of tert-butanesulfinimines: convenient access to chiral aziridines.
机构信息
School of Chemistry, University of Nottingham, Nottingham, UK NG7 2RD.
出版信息
Org Biomol Chem. 2011 Jul 21;9(14):5034-5. doi: 10.1039/c1ob05561e. Epub 2011 Jun 3.
PMID:21643589
Abstract
Stereoselective synthesis of 2,3-di- and 2,2',3-tri-substituted aziridines in good yields and excellent diastereoselectivities are achieved through aza-Darzens reactions of a range of tert-butanesulfinyl aldimines and ketimines with ethyl bromoacetate.
摘要
通过一系列叔丁基亚磺酰基醛亚胺和酮亚胺与溴乙酸乙酯的氮杂-Darzens 反应，以良好的收率和优异的非对映选择性实现了 2,3-二取代和 2,2',3-三取代氮丙啶的立体选择性合成。
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